Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 4/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 2/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.39 |
| ▸ | CCR2 | P41597 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.38 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.38 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6690216 | 0.96 | PLA2G2A (0.43) | PLA2G2APLA2G1BPGRSERPINE1CCR2 | |
| SCHEMBL6770631 | 0.94 | PLA2G2A (0.46) | PLA2G2APLA2G1BSERPINE1KLKB1KLK1 | |
| SCHEMBL6771677 | 0.92 | PLA2G2A (0.41) | PLA2G2APLA2G1BPGRCCR2PPARG | |
| SCHEMBL6776758 | 0.92 | PLA2G2A (0.50) | PLA2G2APLA2G1BPGRCCR2ALDH1A1 | |
| SCHEMBL6773052 | 0.92 | PLA2G2A (0.50) | PLA2G2APLA2G1BPGRCCR2ALDH1A1 | |
| SCHEMBL6694433 | 0.92 | PLA2G2A (0.46) | PLA2G2APLA2G1BSERPINE1ALDH1A1 | |
| SCHEMBL6774857 | 0.90 | FAAH (0.43) | PLA2G2ACCR2PPARG | |
| SCHEMBL6775434 | 0.89 | ADRA1D (0.46) | PLA2G2APLA2G1BALDH1A1 | |
| SCHEMBL6772770 | 0.89 | PLA2G2A (0.41) | PLA2G2APLA2G1BALDH1A1 | |
| SCHEMBL6776710 | 0.89 | PLA2G2A (0.41) | PLA2G2APLA2G1BERCC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |