Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ECE1 | P42892 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6773425 | 0.89 | PLA2G2A (0.42) | ALDH1A1KDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL6898392 | 0.88 | L3MBTL1 (0.44) | ALDH1A1KDM4ENPC1RAB9ANOD2 | |
| SCHEMBL6693619 | 0.88 | ALDH1A1 (0.47) | ALDH1A1KDM4ENPC1RAB9ANOD2 | |
| SCHEMBL6773681 | 0.88 | ALDH1A1 (0.42) | ALDH1A1KDM4ENPC1RAB9ANOD2 | |
| SCHEMBL6773917 | 0.87 | ALDH1A1 (0.44) | ALDH1A1KDM4ENPC1RAB9ANOD2 | |
| SCHEMBL6776472 | 0.87 | PLA2G2A (0.44) | ALDH1A1KDM4ENOD2L3MBTL1MAPT | |
| SCHEMBL6776254 | 0.87 | CD38 (0.41) | ALDH1A1TSHRKMT2AMEN1HTT | |
| SCHEMBL6774832 | 0.87 | CD38 (0.44) | ALDH1A1KDM4EKMT2AMEN1AURKA | |
| SCHEMBL6776187 | 0.87 | ALDH1A1 (0.42) | ALDH1A1KDM4ENPC1RAB9ANOD2 | |
| SCHEMBL6781636 | 0.86 | MCL1 (0.45) | KDM4EKMT2AMEN1AURKARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |