Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6892544 | 0.89 | MAPT (0.44) | L3MBTL1LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL6691803 | 0.89 | LMNA (0.47) | L3MBTL1LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL6892764 | 0.89 | LMNA (0.44) | L3MBTL1LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL6894204 | 0.89 | L3MBTL1 (0.44) | L3MBTL1LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL6775481 | 0.88 | ALDH1A1 (0.44) | L3MBTL1LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL6894986 | 0.88 | HSP90AA1 (0.38) | L3MBTL1LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL6897295 | 0.88 | MAPT (0.48) | L3MBTL1LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL6898407 | 0.87 | YWHAH (0.43) | L3MBTL1LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL6896006 | 0.87 | RORC (0.42) | KDM4EKMT2AMEN1RORCHSP90AA1 | |
| SCHEMBL6896629 | 0.87 | MAPK8 (0.47) | L3MBTL1ALDH1A1KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |