Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNPAT | O15228 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | PAM | P19021 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 3/20 | 0.43 |
| ▸ | ACE | P12821 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27744244 | 0.84 | KMT2A (0.41) | ALOX15KDM4EMAPTSMN1; SMN2MME | |
| SCHEMBL27744242 | 0.84 | KMT2A (0.41) | ALOX15KDM4EMAPTSMN1; SMN2MME | |
| SCHEMBL7059635 | 0.84 | ERAP2 (0.48) | GNPATTNFALOX15ITGB3ITGA2B | |
| SCHEMBL8815317 | 0.83 | L3MBTL1 (0.52) | GNPATTNFALOX15LMNACTSS | |
| SCHEMBL503585 | 0.81 | TNF (0.53) | GNPATTNFALOX15ITGB3ITGA2B | |
| SCHEMBL29398464 | 0.81 | CTSS (0.48) | GNPATTNFALOX15LMNACTSS | |
| SCHEMBL2152925 | 0.81 | TNF (0.50) | GNPATTNFALOX15LMNACTSS | |
| SCHEMBL2153481 | 0.81 | CTSS (0.48) | GNPATTNFALOX15LMNACTSS | |
| SCHEMBL6377776 | 0.81 | TNF (0.50) | GNPATTNFALOX15LMNACTSS | |
| SCHEMBL503584 | 0.81 | TNF (0.53) | GNPATTNFALOX15ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6833382-B2 | By muta-synthesis using a mutated micro-organism to influence the biosynthesis of at least one of the precursors of group B streptogramines; mutant strain employed is preferably derived from the strain S. pristinaespiralis SP92 | AVENTIS PHARMA S.A. (FR) | 2004-12-21 | — | — | US | disclosed |