Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6770631 | 0.91 | PLA2G2A (0.46) | PLA2G2AF10PARP1PLA2G1BERCC5 | |
| SCHEMBL6694433 | 0.91 | PLA2G2A (0.46) | PLA2G2APARP1PLA2G1BPLA2G10ADRA1D | |
| SCHEMBL6776710 | 0.91 | PLA2G2A (0.41) | PLA2G2AF10PARP1PLA2G1BPARP2 | |
| SCHEMBL6774933 | 0.88 | PLA2G2A (0.42) | PLA2G2AF10PLA2G1BPLA2G10 | |
| SCHEMBL6778315 | 0.88 | F10 (0.46) | PLA2G2AF10PARP1PARP2ERCC5 | |
| SCHEMBL6774185 | 0.88 | TP53 (0.47) | PLA2G2AF10PARP1PLA2G1BPARP2 | |
| SCHEMBL6773052 | 0.88 | PLA2G2A (0.50) | PLA2G2AF10PLA2G1BADRA1D | |
| SCHEMBL6770537 | 0.88 | FABP3 (0.41) | PLA2G2AF10PLA2G1BFEN1PLA2G10 | |
| SCHEMBL6889569 | 0.87 | MAPK8 (0.43) | PLA2G2APLA2G1BCFTRMAPK8CYP19A1 | |
| SCHEMBL6775492 | 0.86 | PLA2G2A (0.41) | PLA2G2AF10PARP1PARP2ERCC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |