Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 9/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6776758 | 0.94 | PLA2G2A (0.50) | PLA2G2ACCR2PLA2G1BL3MBTL1ATG4B | |
| SCHEMBL6694433 | 0.94 | PLA2G2A (0.46) | PLA2G2APLA2G1BL3MBTL1MAPTALDH1A1 | |
| SCHEMBL6776773 | 0.92 | PLA2G2A (0.42) | PLA2G2ACCR2PLA2G1BALDH1A1PGR | |
| SCHEMBL6690216 | 0.92 | PLA2G2A (0.43) | PLA2G2ACCR2PLA2G1BL3MBTL1ALDH1A1 | |
| SCHEMBL6770631 | 0.91 | PLA2G2A (0.46) | PLA2G2APLA2G1BL3MBTL1ALDH1A1F10 | |
| SCHEMBL6774933 | 0.88 | PLA2G2A (0.42) | PLA2G2APLA2G1BF10 | |
| SCHEMBL6771677 | 0.88 | PLA2G2A (0.41) | PLA2G2ACCR2PLA2G1BL3MBTL1ATG4B | |
| SCHEMBL6690183 | 0.88 | PLA2G2A (0.62) | PLA2G2ACCR2PLA2G1BL3MBTL1ATG4B | |
| SCHEMBL6775875 | 0.88 | PLA2G2A (0.40) | PLA2G2APLA2G1BADRA1DF10 | |
| SCHEMBL6774185 | 0.88 | TP53 (0.47) | PLA2G2APLA2G1BL3MBTL1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |