Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.58 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 4/20 | 0.53 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775637 | 0.86 | MTNR1A (0.59) | MTNR1AMTNR1BHTR2AHTR6SCN5A | |
| SCHEMBL2013301 | 0.85 | MTNR1A (0.58) | MTNR1AMTNR1BHTR2AHTR6SCN5A | |
| Hydrochloric Acid SCHEMBL28174730 | 0.84 | MTNR1A (0.57) | MTNR1AMTNR1BHTR2AHTR6SCN5A | |
| Hydrochloric Acid SCHEMBL28174732 | 0.84 | MTNR1A (0.57) | MTNR1AMTNR1BHTR2AHTR6SCN5A | |
| SCHEMBL24328893 | 0.80 | MTNR1A (0.57) | MTNR1AMTNR1BHTR2AHTR6SCN5A | |
| SCHEMBL24328917 | 0.80 | SMN1; SMN2 (0.60) | MTNR1AMTNR1BHTR2AHTR6SCN5A | |
| SCHEMBL28409765 | 0.80 | SMN1; SMN2 (0.60) | MTNR1AMTNR1BHTR2AHTR6SCN5A | |
| SCHEMBL2013303 | 0.79 | KMT2A (0.61) | MTNR1AMTNR1BHTR2AHTR6SCN5A | |
| SCHEMBL1461064 | 0.79 | KMT2A (0.61) | MTNR1AMTNR1BHTR2AHTR6SCN5A | |
| SCHEMBL1461062 | 0.79 | KMT2A (0.61) | MTNR1AMTNR1BHTR2AHTR6SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| EP-0950661-B1 | Substituted tricyclics useful in sPLA2 induced diseases | LILLY CO ELI (US) | 2003-11-12 | — | — | EP | disclosed |
| EP-1156050-A2 | Substituted tricyclics useful in sPLA2 induced diseases | ELI LILLY AND COMPANY (US) | 2001-11-21 | — | — | EP | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0950661-A1 | Substituted tricyclics useful in sPLA2 induced diseases | ELI LILLY AND COMPANY (US) | 1999-10-20 | — | — | EP | disclosed |