Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 7/20 | 0.44 |
| ▸ | BAD | Q92934 | 7/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | CD38 | P28907 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775459 | 0.92 | MCL1 (0.48) | MCL1BADPLA2G1BPLA2G2AMEN1 | |
| SCHEMBL6777226 | 0.89 | ADRA1D (0.43) | PLA2G2AMEN1KMT2AF10CD38 | |
| SCHEMBL6889876 | 0.89 | MAPK8 (0.44) | MCL1BADPLA2G1BPLA2G2AMEN1 | |
| SCHEMBL6770301 | 0.87 | PLA2G2A (0.41) | PLA2G2AMEN1KMT2ACD38ALDH1A1 | |
| SCHEMBL6771780 | 0.87 | IKBKB (0.37) | PLA2G2ACD38AURKARPS6KB1 | |
| SCHEMBL6782583 | 0.87 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL6775902 | 0.86 | PLA2G2A (0.42) | MCL1BADPLA2G1BPLA2G2ACYP2C19 | |
| SCHEMBL7968444 | 0.86 | PLA2G2A (0.53) | MCL1BADPLA2G1BPLA2G2AMEN1 | |
| SCHEMBL6690216 | 0.86 | PLA2G2A (0.43) | PLA2G1BPLA2G2AMEN1KMT2AALDH1A1 | |
| SCHEMBL6770388 | 0.86 | PLA2G2A (0.41) | PLA2G1BPLA2G2AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |