Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 8/20 | 0.48 |
| ▸ | BAD | Q92934 | 8/20 | 0.48 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CD38 | P28907 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6776015 | 0.92 | MCL1 (0.44) | MCL1BADPLA2G1BPLA2G2ACMA1 | |
| SCHEMBL6690888 | 0.88 | MEN1 (0.47) | MCL1BADPLA2G1BPLA2G2ACMA1 | |
| SCHEMBL6895068 | 0.88 | MAPK8 (0.47) | MCL1BADPLA2G1BPLA2G2ACMA1 | |
| SCHEMBL6781636 | 0.88 | MCL1 (0.45) | MCL1BADPLA2G1BPLA2G2ACMA1 | |
| SCHEMBL6775731 | 0.87 | PLA2G2A (0.46) | MCL1BADPLA2G1BPLA2G2AGRM2 | |
| SCHEMBL6782214 | 0.86 | PARP1 (0.39) | MCL1BADPLA2G1BPLA2G2ACD38 | |
| SCHEMBL6773917 | 0.86 | ALDH1A1 (0.44) | KMT2AKDM4ENPC1GAAMAPT | |
| SCHEMBL6776614 | 0.86 | PLA2G2A (0.44) | PLA2G2AMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL6777361 | 0.86 | PLA2G2A (0.46) | PLA2G1BPLA2G2AMEN1KMT2AKDM4E | |
| SCHEMBL6776083 | 0.86 | PLA2G1B (0.42) | MCL1BADPLA2G1BPLA2G2ACMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |