Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | CD38 | P28907 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 7/20 | 0.40 |
| ▸ | BAD | Q92934 | 7/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6896536 | 0.90 | MAPK8 (0.47) | PLA2G1BPLA2G2AMCL1BADF10 | |
| SCHEMBL6778112 | 0.90 | PPARG (0.40) | PLA2G1BPLA2G2ACD38MCL1BAD | |
| SCHEMBL6781636 | 0.88 | MCL1 (0.45) | PLA2G1BPLA2G2ACD38MCL1BAD | |
| SCHEMBL6780594 | 0.88 | MEN1 (0.43) | PLA2G1BPLA2G2ACD38MEN1KMT2A | |
| SCHEMBL6773681 | 0.87 | ALDH1A1 (0.42) | MEN1KMT2AKDM4E | |
| SCHEMBL6776238 | 0.87 | CD38 (0.38) | PLA2G1BPLA2G2ACD38MEN1KMT2A | |
| SCHEMBL6771810 | 0.87 | ALDH1A1 (0.42) | PLA2G2ACD38F10MEN1KMT2A | |
| SCHEMBL6690888 | 0.86 | MEN1 (0.47) | PLA2G1BPLA2G2ACD38MCL1BAD | |
| SCHEMBL6776234 | 0.86 | PLA2G2A (0.47) | PLA2G1BPLA2G2APARP1 | |
| SCHEMBL6775459 | 0.86 | MCL1 (0.48) | PLA2G1BPLA2G2ACD38MCL1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |