SCHEMBL677629

SCHEMBL677629

CC1C(=O)c2ccccc2C1=O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 6/20 0.55
KMT2A Q03164 6/20 0.55
S100A4 P26447 3/20 0.55
POLB P06746 2/20 0.55
MAPT P10636 5/20 0.50
TP53 P04637 3/20 0.50
LMNA P02545 2/20 0.50
MAPK1 P28482 2/20 0.50
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
HTR2B P41595 1/20 0.50
ACHE P22303 1/20 0.48
PIM1 P11309 1/20 0.48
HBB P68871 2/20 0.46
ALDH1A1 P00352 1/20 0.46
HSD17B10 Q99714 1/20 0.46
CDC25B P30305 1/20 0.45
NPC1 O15118 4/20 0.43
RAB9A P51151 4/20 0.43
SMN1; SMN2 Q16637 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12646072 0.97 MEN1 (0.52) MEN1KMT2AS100A4POLBMAPT
SCHEMBL23043831 0.90 MEN1 (0.50) MEN1KMT2AS100A4POLBMAPT
SCHEMBL22272424 0.90 MEN1 (0.50) MEN1KMT2AS100A4POLBMAPT
SCHEMBL30273837 0.83 MEN1 (0.50) MEN1KMT2AS100A4POLBMAPT
SCHEMBL15245116 0.82 MEN1 (0.55) MEN1KMT2AS100A4POLBMAPT
SCHEMBL12464114 0.79 GSTP1 (0.40) MEN1KMT2AS100A4POLBTP53
SCHEMBL13302890 0.78 ALDH1A1 (0.56) MEN1KMT2APOLBMAPTTP53
SCHEMBL16975948 0.77 ACHE (0.33) MEN1KMT2AS100A4POLBACHE
SCHEMBL20924856 0.76 ACHE (0.59) MEN1KMT2AS100A4POLBMAPT
SCHEMBL8293271 0.76 TSHR (0.48) MEN1KMT2AS100A4POLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 231 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4649963-A2 IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE Arvinas Operations, Inc. (US) 2025-11-19 EP disclosed
EP-4509184-A2 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR Arvinas Operations, Inc. (US) 2025-02-19 EP disclosed
US-20250034096-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR ARVINAS OPERATIONS, INC. 2025-01-30 US disclosed
EP-3526202-B1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR ARVINAS OPERATIONS INC (US) 2025-01-08 EP disclosed
US-20240368179-A1 IMIDE-BASED MODULATORS OF PROTEOLYSIS AND METHODS OF USE UNIV YALE (US) 2024-11-07 US disclosed
US-20240299366-A1 IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2024-09-12 US disclosed
EP-3302572-B3 IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS INC (US) 2024-07-24 EP disclosed
US-20240158428-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2024-05-16 US disclosed
US-11964945-B2 Compounds and methods for the targeted degradation of androgen receptor ARVINAS OPERATIONS, INC. (US) 2024-04-23 US disclosed
US-11952347-B2 Compounds and methods for the targeted degradation of androgen receptor ARVINAS OPERATIONS, INC. (US) 2024-04-09 US disclosed
EP-1002516-A1 Hair dyes containing indan derivatives Wella Aktiengesellschaft (DE) 2000-05-24 EP disclosed
US-5994012-A CHARGE GENERATING COMPOUND, CHARGE TRANSFER COMPOUND AND BINDER MITA INDUSTRIAL CO., LTD. (JP) 1999-11-30 US disclosed
US-5863688-A REACTING 1,3-INDANDIONE DERIVATIVE WITH A BROMOACETIC ESTER TO FORM 1,3-INDANDIONE ESTER, ISOMERIZING THE ESTER DERIVATIVE IN PRESENCE OF SODIUM HYDRIDE TO FORM NAPHTHOIC ESTER, OXIDIZING TO FORM NAPHTHOQUINONE DERIVATIVE MITA INDUSTRIAL CO., LTD (JP) 1999-01-26 US disclosed
EP-0764886-A2 Naphthoquinone derivative and electrophotosensitive material using the same MITA INDUSTRIAL CO. LTD. (JP) 1997-03-26 EP disclosed
WO-1995011001-A1 1,3-PROPANDIONES FOR DYEING KERATINIC FIBRES HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1995-04-27 WO disclosed
EP-0398258-B1 INDAN-1,3-DIONE DERIVATIVE AND HERBICIDAL COMPOSITION CONTAINING THE SAME AS ACTIVE INGREDIENT MITSUBISHI KASEI CORPORATION (JP) 1993-08-04 EP disclosed
US-5110342-A INDAN-1,3-DIONE DERIVATIVE AND HERBICIDAL COMPOSITION CONTAINING THE SAME AS ACTIVE INGREDIENT MITSUBISHI KASEI CORPORATION (JP) 1992-05-05 US disclosed
US-5076830-A INDAN-1,3-DIONE DERIVATIVE AND HERBICIDAL COMPOSITION CONTAINING THE SAME AS ACTIVE INGREDIENT MITSUBISHI KASEI CORPORATION (JP) 1991-12-31 US disclosed
US-4987056-A IMPROVED SENSITIVITY TO VISIBLE LIGHT TOYO BOSEKI KABUSHIKI KAISHA (JP) 1991-01-22 US disclosed
EP-0398258-A1 Indan-1,3-dione derivative and herbicidal composition containing the same as active ingredient MITSUBISHI KASEI CORPORATION (JP) 1990-11-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240158428-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD1, OCIAD2, ICOSLG MEN1 2834/4885KMT2A 3760/4885S100A4 2739/4885
US-20240299366-A1 IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE CRBN, MDM2, UBE2N MEN1 1077/4885KMT2A 1660/4885S100A4 2728/4885
US-11964945-B2 Compounds and methods for the targeted degradation of androgen receptor AR, ADRM1, CRBN MEN1 1676/4885KMT2A 1478/4885S100A4 4302/4885
US-11952347-B2 Compounds and methods for the targeted degradation of androgen receptor AR, ADRM1, CRBN MEN1 1674/4885KMT2A 1463/4885S100A4 4293/4885
US-20240368179-A1 IMIDE-BASED MODULATORS OF PROTEOLYSIS AND METHODS OF USE CRBN, MDM2, UBE2N MEN1 746/4885KMT2A 1686/4885S100A4 2758/4885
US-20250034096-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR AR, ADRM1, CRBN MEN1 1674/4885KMT2A 1463/4885S100A4 4293/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.