Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6163485 | 0.89 | ALDH1A1 (0.38) | LMNATSHRHTTSRCALDH1A1 | |
| SCHEMBL6778055 | 0.88 | SRC (0.43) | LMNATSHRHTTSRCALDH1A1 | |
| SCHEMBL6770710 | 0.87 | SRC (0.50) | LMNATSHRHTTSRCALDH1A1 | |
| SCHEMBL6770294 | 0.84 | SRC (0.36) | LMNASRCALDH1A1KDM4ETRPV1 | |
| SCHEMBL6771450 | 0.84 | OPRM1 (0.46) | LMNAHTTSRCALDH1A1OPRM1 | |
| SCHEMBL6770749 | 0.83 | SRC (0.35) | LMNASRCALDH1A1KDM4EHPGD | |
| SCHEMBL6766716 | 0.82 | HTT (0.37) | LMNATSHRHTTSRCALDH1A1 | |
| SCHEMBL6163994 | 0.80 | HTT (0.39) | LMNATSHRHTTALDH1A1MAPT | |
| SCHEMBL6771081 | 0.80 | ALDH1A1 (0.58) | LMNATSHRHTTSRCALDH1A1 | |
| SCHEMBL6772487 | 0.80 | SRC (0.53) | LMNATSHRHTTSRCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |