Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | GRK6 | P43250 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178361 | 0.85 | HSP90AA1 (0.40) | PTGS2HSP90AA1HSP90AB1CRBN | |
| SCHEMBL6776879 | 0.81 | PTGS2 (0.61) | PTGS2 | |
| SCHEMBL6773232 | 0.73 | PTGS2 (0.43) | PTGS2HSP90AA1HSP90AB1CRBN | |
| SCHEMBL13955779 | 0.69 | ALDH1A1 (0.46) | PTGS2HSP90AA1HSP90AB1 | |
| SCHEMBL16714473 | 0.69 | PTGS2 (0.36) | PTGS2HSP90AA1HSP90AB1 | |
| SCHEMBL16724610 | 0.69 | APP (0.46) | — | |
| SCHEMBL16724628 | 0.69 | HSP90AA1 (0.36) | PTGS2HSP90AA1HSP90AB1GRM5 | |
| SCHEMBL14227622 | 0.68 | PTGS1 (0.43) | PTGS2HSP90AA1HSP90AB1CRBN | |
| SCHEMBL15703332 | 0.67 | APP (0.48) | — | |
| SCHEMBL6291094 | 0.67 | PTGS2 (0.64) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6743816-B2 | CYCLOOXYGENASE INHIBITORS WITH SELECTIVITY FOR THE ISOFORM 2 (COX-2); 4-CHLORO-5-(4-ISOPROPOXYPHENYL)-1-(4-METHYLSULFONYL PHENYL)IMIDAZOLE; CHLORINATION | J. URIACH & CIA S.A. (ES) | 2004-06-01 | — | — | US | disclosed |
| US-20030176481-A1 | Novel imidazole derivatives with anti-inflammatory activity | J. URIACH & CIA S.A. (ES) | 2003-09-18 | — | — | US | disclosed |
| EP-1270559-A1 | NOVEL IMIDAZOLE DERIVATIVES WITH ANTI-INFLAMMATORY ACTIVITY | J. URIACH & CIA. S.A. (ES) | 2003-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176481-A1 | Novel imidazole derivatives with anti-inflammatory activity | IL1B, IL1A, MIF | PTGS2 11/4885GRK6 1711/4885HSP90AA1 542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.