Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 16/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7537151 | 0.84 | OPRM1 (0.54) | OPRM1SRC | |
| SCHEMBL6767006 | 0.81 | OPRM1 (0.58) | OPRM1HSP90AB1OPRD1OPRK1SRC | |
| SCHEMBL6770141 | 0.81 | PTGS1 (0.41) | OPRM1PTGS1 | |
| SCHEMBL7534112 | 0.80 | OPRM1 (0.50) | OPRM1HSP90AB1OPRD1OPRK1SRC | |
| SCHEMBL6776854 | 0.79 | PTGS1 (0.42) | PTGS1 | |
| SCHEMBL7483415 | 0.79 | OPRM1 (0.49) | OPRM1HSP90AB1OPRD1OPRK1SRC | |
| SCHEMBL7537240 | 0.79 | OPRM1 (0.58) | OPRM1SRC | |
| SCHEMBL6770401 | 0.79 | OPRM1 (0.77) | OPRM1HSP90AB1OPRD1OPRK1 | |
| SCHEMBL7484568 | 0.78 | OPRM1 (0.50) | OPRM1HSP90AB1OPRD1OPRK1SRC | |
| SCHEMBL7479730 | 0.77 | OPRM1 (0.54) | OPRM1HSP90AB1OPRD1OPRK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |