Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 6/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.52 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | HTR1D | P28221 | 3/20 | 0.52 |
| ▸ | HTR1B | P28222 | 3/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11753819 | 0.86 | BRPF1 (0.70) | BRPF1MAPK14LCKKDRCHRM5 | |
| SCHEMBL6781323 | 0.81 | TSHR (0.54) | MAPK14KMT2AMAPK1MEN1SMN1; SMN2 | |
| SCHEMBL27527545 | 0.80 | BRAF (0.59) | MAPK14LCKKDRCHRM5CHRM1 | |
| SCHEMBL6777434 | 0.79 | HPGDS (0.64) | MAPK14LCKKDRKMT2AMAPK1 | |
| SCHEMBL6782017 | 0.79 | ALDH1A1 (0.60) | MAPK14KMT2AMEN1SMN1; SMN2USP2 | |
| SCHEMBL7600252 | 0.77 | IDH2 (0.53) | MAPK14CHRM1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11752282 | 0.76 | BRPF1 (0.57) | BRPF1CHRM5CHRM1CHRM3KMT2A | |
| Hydrochloric Acid SCHEMBL11753405 | 0.75 | BRPF1 (0.56) | BRPF1CHRM5CHRM1CHRM3KMT2A | |
| SCHEMBL5910645 | 0.74 | MAPT (0.80) | KMT2AMAPK1SMN1; SMN2USP2POLB | |
| SCHEMBL2951290 | 0.73 | MAPK14 (1.00) | MAPK14LCKKDRKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686467-B2 | INHIBITORS OF THE PRODUCTION OF CYTOKINES SUCH AS TUMOUR NECROSIS FACTOR (HEREINAFTER TNF), FOR EXAMPLE TNF ALPHA , AND VARIOUS MEMBERS OF THE INTERLEUKIN (HEREINAFTER IL) FAMILY, FOR EXAMPLE IL-1, IL-6 AND IL-8 | ZENECA LIMITED (GB) | 2004-02-03 | — | — | US | claimed |