Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.48 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.48 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974566 | 0.82 | MAPK14 (0.58) | MAPK14RAF1BRAF | |
| SCHEMBL27527545 | 0.78 | BRAF (0.59) | MAPK14CHRM1RAF1BRAF | |
| SCHEMBL6779151 | 0.77 | HPGDS (0.61) | ALDH1A1KDM4ESMN1; SMN2MAPK14MAPT | |
| SCHEMBL6777439 | 0.77 | BRPF1 (0.59) | ALDH1A1HPGDPOLBSMN1; SMN2KCNK3 | |
| SCHEMBL6778190 | 0.77 | KMT2A (0.71) | ALDH1A1KDM4EHPGDPOLBSMN1; SMN2 | |
| SCHEMBL6781323 | 0.77 | TSHR (0.54) | ALDH1A1POLBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6782017 | 0.75 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDPOLBSMN1; SMN2 | |
| SCHEMBL6309797 | 0.75 | HTR5A (0.56) | ALDH1A1KDM4EHPGDPOLBSMN1; SMN2 | |
| SCHEMBL5563711 | 0.74 | SMN1; SMN2 (0.72) | ALDH1A1KDM4EHPGDPOLBSMN1; SMN2 | |
| SCHEMBL31606985 | 0.73 | MT-CO2 (0.78) | ALDH1A1HPGDSMN1; SMN2MT-CO2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017378-B1 | AMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 2002-12-11 | — | — | EP | claimed |