Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7823801 | 0.91 | KMT2A (0.43) | GPR139KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7833244 | 0.91 | GPR139 (0.43) | GPR139KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7338364 | 0.90 | GPR139 (0.45) | GPR139KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6778268 | 0.88 | GPR139 (0.44) | GPR139KMT2AMEN1GPR132CTSL | |
| SCHEMBL6775970 | 0.88 | GPR132 (0.49) | GPR139GPR132CA2 | |
| SCHEMBL3051751 | 0.87 | GPR139 (0.44) | GPR139KMT2AMEN1GPR132CTSL | |
| SCHEMBL7339636 | 0.86 | GPR132 (0.50) | GPR139KMT2ASMN1; SMN2ALDH1A1GPR132 | |
| SCHEMBL7347036 | 0.86 | HPGD (0.42) | GPR139KMT2ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7823171 | 0.85 | ITGB3 (0.50) | GPR132 | |
| SCHEMBL7343510 | 0.85 | GPR139 (0.51) | GPR139KMT2AMEN1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| US-6831199-B1 | In order to avoid bleeding side-effects when treating the conditions associated with integrin alpha v beta 3, it is beneficial to have compounds which are selective antagonists for alpha v beta 3 versus alpha IIb beta 3 | G. D. SEARLE & CO. | 2004-12-14 | — | — | US | disclosed |