Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 9/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.41 |
| ▸ | ITGAV | P06756 | 5/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.41 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.41 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.41 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.39 |
| ▸ | MDM4 | O15151 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6778010 | 0.91 | GPR139 (0.49) | GPR139GPR132ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL7837425 | 0.91 | GPR139 (0.40) | GPR139ITGB1ITGB3ITGAVITGA5 | |
| SCHEMBL7823801 | 0.90 | KMT2A (0.43) | GPR139ITGB1ITGB3ITGAVITGA2B | |
| SCHEMBL6778268 | 0.86 | GPR139 (0.44) | GPR139ITGB1ITGB3ITGAVITGA2B | |
| SCHEMBL6775970 | 0.86 | GPR132 (0.49) | GPR139ITGB1ITGB3ITGAVITGA2B | |
| SCHEMBL3051751 | 0.85 | GPR139 (0.44) | GPR139ITGB1ITGB3ITGAVITGB5 | |
| SCHEMBL6777818 | 0.85 | ITGB3 (0.45) | GPR139ITGB1ITGB3ITGAVITGA2B | |
| SCHEMBL7339636 | 0.85 | GPR132 (0.50) | GPR139GPR132ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7823171 | 0.83 | ITGB3 (0.50) | ITGB1ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL7340682 | 0.83 | ALDH1A1 (0.47) | GPR139ITGB1ITGB3ITGAVITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |