Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6785331 | 0.81 | TP53 (0.52) | POLBKMT2A | |
| SCHEMBL8116591 | 0.79 | GLA (0.63) | GLAGAAKDM4EALDH1A1HPGD | |
| SCHEMBL8930316 | 0.79 | ABCB1 (0.44) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL6781777 | 0.79 | TP53 (0.50) | GAAKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL6779130 | 0.77 | ADRA1D (0.60) | ADRA1DADRA1AADRA1B | |
| SCHEMBL5462447 | 0.76 | ADRA1D (0.73) | ADRA1DADRA1AADRA1B | |
| SCHEMBL13941828 | 0.75 | LMNA (0.68) | GLAGAALMNAADRA1DADRA1A | |
| SCHEMBL15887987 | 0.74 | KDM4E (0.62) | GLAGAAKDM4EALDH1A1HPGD | |
| SCHEMBL1512503 | 0.74 | ADRA1D (0.77) | ADRA1DADRA1AADRA1B | |
| SCHEMBL6780800 | 0.74 | ADRA1D (0.61) | ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6706705-B1 | SLOW AND CONTINUOUS BLOOD PRESSURE REDUCING ACTION AND IS USEFUL AS AN ANTIHYPERTENSIVE AGENT | NIPPON CHEMIPHAR CO., LTD. (JP) | 2004-03-16 | — | — | US | disclosed |
| EP-0794178-A1 | QUINAZOLINE DERIVATIVE | NIPPON CHEMIPHAR CO., LTD. (JP) | 1997-09-10 | — | — | EP | disclosed |