Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 6/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5688713 | 0.70 | CDK1 (1.00) | CDK1ALDH1A1GSK3BCCNB2CCNB1 | |
| SCHEMBL5688353 | 0.69 | CDK1 (1.00) | CDK1ALDH1A1GSK3BCCNB2CCNB1 | |
| SCHEMBL11807676 | 0.63 | CYP1A2 (0.61) | CDK1ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL31367788 | 0.63 | CASP3 (0.50) | CDK1ALDH1A1CASP3HSD17B10KDM4E | |
| SCHEMBL31367789 | 0.63 | CASP3 (0.50) | CDK1ALDH1A1CASP3HSD17B10KDM4E | |
| SCHEMBL5805683 | 0.60 | CDK1 (0.65) | CDK1ALDH1A1GSK3BCCNB2CCNB1 | |
| SCHEMBL3776134 | 0.60 | NAMPT (0.47) | CDK1ALDH1A1CASP3HSD17B10KDM4E | |
| SCHEMBL11806794 | 0.60 | RAB9A (0.74) | CDK1ALDH1A1HSD17B10KDM4EMAPT | |
| SCHEMBL5237362 | 0.59 | CDK1 (0.81) | CDK1ALDH1A1GSK3BCCNB2CCNB1 | |
| SCHEMBL24819639 | 0.59 | CASP3 (0.51) | CDK1ALDH1A1CASP3KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879591-B1 | USE OF AZAPAULLONES FOR PREVENTING AND TREATING PANCREATIC AUTOIMMUNE DISORDERS | DEVELOGEN AG (DE) | 2012-01-25 | — | — | EP | disclosed |
| US-7968535-B2 | Antidiabetic agents; neurodegenerative disorders; mixture with immunosuppresants | DEVELOGEN ATKIENGESELLSCHAFT (DE) | 2011-06-28 | — | — | US | disclosed |
| US-20080287423-A1 | Use of Azapaullones For Preventing and Treating Pancreatic Autoimmune Disorders | EVOTEC INTERNATIONAL GMBH (DE) | 2008-11-20 | — | — | US | disclosed |
| US-20080287423-A1 | Use of Azapaullones For Preventing and Treating Pancreatic Autoimmune Disorders | EVOTEC INTERNATIONAL GMBH (DE) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287423-A1 | Use of Azapaullones For Preventing and Treating Pancreatic Autoimmune Disorders | IAPP, RNASE1, AMY2A | CDK1 3832/4885ALDH1A1 624/4885CASP3 346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.