Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27858771 | 0.82 | PTPN1 (0.52) | NPC1RAB9APTPN1CA1CA2 | |
| SCHEMBL8478498 | 0.81 | HDAC4 (0.45) | NPC1RAB9APTPN1HTR7PLOD2 | |
| SCHEMBL105102 | 0.80 | GSK3B (0.55) | NPC1RAB9ACA1CA2CES2 | |
| SCHEMBL26687976 | 0.80 | MAPK1 (0.57) | NPC1RAB9AMAPTLMNAGSK3B | |
| SCHEMBL26966709 | 0.80 | KMT2A (0.44) | NPC1CA1CA2CES1MAPT | |
| SCHEMBL9386214 | 0.80 | GSK3B (0.55) | NPC1RAB9ACA1CA2CES2 | |
| SCHEMBL104262 | 0.80 | GSK3B (0.53) | NPC1RAB9ACES2CES1MAPT | |
| SCHEMBL2867066 | 0.80 | GSK3B (0.67) | CA1CA2CES2CES1MAPT | |
| SCHEMBL4658864 | 0.79 | PTPN1 (0.58) | PTPN1CES2CES1MAPTGSK3B | |
| SCHEMBL9035708 | 0.79 | CES2 (0.55) | NPC1RAB9ACES2CES1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117924177-A | Preparation method of pazopanib intermediate 2, 3-dimethyl-6-amino-2H-indazole and analogues thereof | 南京杰运医药科技有限公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-111704630-A | 3-arylformyl naphtho-isoxazole or 3-arylformyl anthraceno-isoxazole derivative and synthetic method thereof | 上海大学 | 2020-09-25 | — | — | CN | disclosed |
| CN-101985424-B | Method for synthesizing o-nitroacetophenone compound | UNIV ZHEJIANG TECHNOLOGY | 2013-05-29 | — | — | CN | disclosed |
| CN-101985424-A | Method for synthesizing o-nitroacetophenone compound | UNIV ZHEJIANG TECHNOLOGY | 2011-03-16 | — | — | CN | disclosed |
| US-6686505-B2 | HYDROGENATION OF NITRO KETONE OR CYANO KETONE IN PRESENCE OF TRANSITION METAL COMPOUND CATALYST; AMINATION | KANTO KAGUKU KABUSHIKI KAISHA (JP) | 2004-02-03 | — | — | US | disclosed |
| US-20030171592-A1 | Process for producing optically active amino alcohols and intermediates therefore | KANTO KAGAKU KABUSHIKI KAISHA (JP) | 2003-09-11 | — | — | US | disclosed |
| EP-1308435-A2 | Process for producing optically active amino alcohols | Kanto Kagaku Kabushiki Kaisha (JP) | 2003-05-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171592-A1 | Process for producing optically active amino alcohols and intermediates therefore | ADH1A, NOS1, ADH5 | NPC1 3259/4885RAB9A 2501/4885PTPN1 4827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.