Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 3/20 | 0.49 |
| ▸ | CCR2 | P41597 | 10/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308528 | 0.82 | CCR2 (0.53) | ABCB11CCR2MAPTTDP1KDM4E | |
| SCHEMBL6595112 | 0.82 | CCR2 (0.59) | ABCB11CCR2MAPTTDP1KDM4E | |
| SCHEMBL6302602 | 0.81 | CCR2 (0.57) | CCR2MAPTTDP1KDM4EMAPK1 | |
| SCHEMBL6780153 | 0.81 | ABCB11 (0.54) | ABCB11CCR2MAPTKDM4EHTT | |
| SCHEMBL7839309 | 0.80 | CCR2 (0.57) | ABCB11CCR2MAPTTDP1KDM4E | |
| SCHEMBL6596419 | 0.80 | ABCB11 (0.57) | ABCB11CCR2MAPTTDP1KDM4E | |
| SCHEMBL6300925 | 0.79 | CCR2 (0.71) | CCR2MAPTTDP1KDM4EMAPK1 | |
| SCHEMBL6599360 | 0.79 | ABCB11 (0.77) | ABCB11CCR2MAPTTDP1KDM4E | |
| SCHEMBL6999936 | 0.78 | CCR2 (0.56) | CCR2MAPTTDP1KDM4EMAPK1 | |
| SCHEMBL6302592 | 0.78 | NOD2 (0.57) | ABCB11CCR2MAPTTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737435-B1 | ANTIINFLAMMATORY AGENTS; MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) DISEASES | ASTRAZENECA AB (SE) | 2004-05-18 | — | — | US | disclosed |