Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSF1 | Q00613 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | BCL6 | P41182 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6786131 | 0.83 | HSF1 (0.55) | HSF1JAK2JAK1MKNK1ROCK2 | |
| SCHEMBL27595866 | 0.75 | HSF1 (0.50) | HSF1MKNK1ROCK2ROCK1EGFR | |
| SCHEMBL6783321 | 0.73 | HSF1 (0.56) | HSF1MKNK1ROCK2ROCK1EGFR | |
| SCHEMBL6909983 | 0.72 | HSF1 (0.51) | HSF1MKNK1ROCK2ROCK1EGFR | |
| SCHEMBL6786129 | 0.70 | HSF1 (0.70) | HSF1MKNK1ROCK2ROCK1EGFR | |
| SCHEMBL27614606 | 0.70 | HSF1 (0.55) | HSF1MKNK1ROCK2ROCK1EGFR | |
| SCHEMBL6782660 | 0.69 | HSF1 (0.53) | HSF1MKNK1ROCK2ROCK1EGFR | |
| SCHEMBL27614696 | 0.69 | HSF1 (0.53) | HSF1MKNK1ROCK2ROCK1EGFR | |
| SCHEMBL6786808 | 0.69 | HSF1 (0.61) | HSF1MKNK1ROCK2ROCK1EGFR | |
| SCHEMBL6786120 | 0.68 | HSF1 (0.63) | HSF1MKNK1ROCK2ROCK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6743795-B1 | INHIBITORS FOR HEPATITIS B AND ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS) BECAUSE THEY INTERFERE WITH REMOVAL OF RNA STRAND FROM RNA-DNA HYBRID FORMED DURING THE REVERSE TRANSCRIPTION OF VIRAL RNA TO DNA | DONG WHA PHARM. IND. CO. LTD. (KR) | 2004-06-01 | — | — | US | disclosed |