Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.76 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | MMP13 | P45452 | 1/20 | 0.61 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | CRHBP | P24387 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6179510 | 0.95 | LMNA (0.83) | LMNAKDM4EHPGDALDH1A1POLB | |
| SCHEMBL2200881 | 0.85 | LMNA (0.73) | LMNAKDM4EHPGDALDH1A1POLB | |
| SCHEMBL12700347 | 0.79 | HPGD (0.72) | LMNAKDM4EHPGDALDH1A1POLB | |
| SCHEMBL2937877 | 0.79 | SMN1; SMN2 (0.70) | LMNAHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL4925396 | 0.79 | MEN1 (0.84) | LMNAHPGDALDH1A1POLBMAPT | |
| SCHEMBL6178238 | 0.79 | HPGD (0.68) | LMNAKDM4EHPGDALDH1A1POLB | |
| SCHEMBL108263 | 0.78 | ALDH1A1 (0.92) | LMNAHPGDALDH1A1POLBMEN1 | |
| SCHEMBL179085 | 0.77 | RAB9A (0.76) | LMNAHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL5335082 | 0.77 | MEN1 (0.90) | LMNAHPGDALDH1A1POLBMEN1 | |
| SCHEMBL6179534 | 0.76 | PKM (0.65) | LMNAKDM4EHPGDALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6784173-B2 | ANTIPROLIFERATIVE AGENTS; ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. | 2004-08-31 | — | — | US | claimed |