Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 5/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 3/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6785653 | 0.85 | ADAM17 (0.49) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6786027 | 0.84 | ADAM17 (0.43) | ADAM17PPARAMMP13MMP9MMP1 | |
| SCHEMBL6782624 | 0.83 | ADAM17 (0.49) | ADAM17MMP13MMP9KDM4EALDH1A1 | |
| SCHEMBL6655628 | 0.82 | ADAM17 (0.42) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6782404 | 0.82 | ADAM17 (0.44) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6787530 | 0.82 | ALDH1A1 (0.44) | ADAM17MMP13MMP9KDM4EALDH1A1 | |
| SCHEMBL6782115 | 0.82 | FFAR1 (0.37) | FFAR1PPARGPPARA | |
| SCHEMBL6785229 | 0.79 | ADAM17 (0.44) | ADAM17PPARAMMP13MMP9MMP1 | |
| SCHEMBL6788196 | 0.79 | ADAM17 (0.41) | ADAM17FFAR1MMP13MMP9ALDH1A1 | |
| SCHEMBL6786265 | 0.79 | ADAM17 (0.44) | ADAM17MMP13MMP9MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825354-B2 | OSTEOPOROSIS; RHEUMATIC DISEASES | WYETH HOLDINGS CORPORATION | 2004-11-30 | — | — | US | disclosed |