Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6788104 | 0.87 | NPC1 (0.53) | LMNAMEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL28096156 | 0.81 | HPGD (0.43) | LMNASMN1; SMN2NPC1RAB9ACYP2D6 | |
| SCHEMBL6789729 | 0.76 | KMT2A (0.62) | LMNAMEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL6789676 | 0.76 | NSD2 (0.45) | LMNAMEN1KMT2ACYP2D6GAA | |
| Dexindoprofen SCHEMBL286896 | 0.69 | NPC1 (1.00) | LMNAMEN1KMT2ATP53SMN1; SMN2 | |
| (R)-Indoprofen SCHEMBL5419435 | 0.69 | NPC1 (1.00) | LMNAMEN1KMT2ATP53SMN1; SMN2 | |
| Indoprofen SCHEMBL29361927 | 0.69 | NPC1 (1.00) | LMNAMEN1KMT2ATP53SMN1; SMN2 | |
| Indoprofen SCHEMBL25137 | 0.69 | NPC1 (1.00) | LMNAMEN1KMT2ATP53SMN1; SMN2 | |
| (R)-Indoprofen SCHEMBL30910963 | 0.69 | NPC1 (1.00) | LMNAMEN1KMT2ATP53SMN1; SMN2 | |
| (R)-Indoprofen SCHEMBL30910962 | 0.69 | NPC1 (1.00) | LMNAMEN1KMT2ATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040019046-A1 | Phenylacetamido-pyrazole derivatives and their use as antitumor agents | PHARMACIA ITALIA SPA (IT) | 2004-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019046-A1 | Phenylacetamido-pyrazole derivatives and their use as antitumor agents | DCK, CCNK, CDK2 | LMNA 3380/4885MEN1 3802/4885KMT2A 1495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.