Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | PGR | P06401 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | DRD1 | P21728 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.62 |
| ▸ | RELA | Q04206 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6783354 | 0.88 | KMT2A (0.53) | KMT2AMEN1TP53SMN1; SMN2LMNA | |
| SCHEMBL11321180 | 0.83 | PLA2G1B (0.56) | KMT2AMEN1TP53SMN1; SMN2LMNA | |
| SCHEMBL11442592 | 0.83 | PLA2G1B (0.52) | KMT2AMEN1TP53SMN1; SMN2LMNA | |
| SCHEMBL14600350 | 0.81 | KMT2A (0.63) | KMT2AMEN1GAARAB9ASCN2A | |
| SCHEMBL29663000 | 0.81 | KMT2A (0.63) | KMT2AMEN1GAARAB9ASCN2A | |
| SCHEMBL11639237 | 0.81 | PLA2G1B (0.56) | KMT2AMEN1GAARAB9ASCN2A | |
| SCHEMBL31207305 | 0.80 | HTR1A (0.64) | KMT2AMEN1GAARAB9ASCN2A | |
| SCHEMBL27264219 | 0.80 | HTR1A (0.64) | KMT2AMEN1GAARAB9ASCN2A | |
| SCHEMBL28557949 | 0.80 | LMNA (0.54) | KMT2AMEN1TP53SMN1; SMN2LMNA | |
| SCHEMBL6788274 | 0.78 | MGLL (0.65) | KMT2AMEN1TP53SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0078709-B1 | PREPARATION OF NITROARALKYL CYANIDES AND DERIVATIVES THEREOF | ETHYL CORPORATION (US) | 1986-10-01 | — | — | EP | claimed |
| EP-0077662-B1 | PREPARATION OF NITROARYLACETIC ACID ESTERS AND DERIVATIVES THEREOF | ETHYL CORPORATION (US) | 1985-10-02 | — | — | EP | claimed |
| US-4499026-A | Nucleophilic substitution process | ETHYL CORPORATION (US) | 1985-02-12 | — | — | US | claimed |
| US-4476315-A | NITROARYLACETIC ACID ESTERS FROM NITROAROMATIC COMPOUNDS | ETHYL CORPORATION (US) | 1984-10-09 | — | — | US | claimed |
| EP-0078709-A2 | Preparation of nitroaralkyl cyanides and derivatives thereof | ETHYL CORPORATION (US) | 1983-05-11 | — | — | EP | claimed |
| EP-0077662-A1 | Preparation of nitroarylacetic acid esters and derivatives thereof | ETHYL CORPORATION (US) | 1983-04-27 | — | — | EP | claimed |
| US-20040019046-A1 | Phenylacetamido-pyrazole derivatives and their use as antitumor agents | PHARMACIA ITALIA SPA (IT) | 2004-01-29 | — | — | US | disclosed |
| EP-1345909-A1 | PHENYLACETAMIDO-PYRAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002048114-A1 | PHENYLACETAMIDO- PYRAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2002-06-20 | — | — | WO | disclosed |
| CN-1017527-B | Process for preparing optically active oxoisoindolinyl derivatives | ERBA FARMITALIA (IT) | 1992-07-22 | — | — | CN | disclosed |
| CN-88101200-A | The preparation method of the oxo-isoindolinyl derivatives of optically-active | — | 1988-10-26 | — | — | CN | disclosed |
| US-4710581-A | Nucleophilic substitution process | ETHYL CORPORATION (US) | 1987-12-01 | — | — | US | disclosed |
| EP-0078709-B1 | PREPARATION OF NITROARALKYL CYANIDES AND DERIVATIVES THEREOF | ETHYL CORPORATION (US) | 1986-10-01 | — | — | EP | disclosed |
| EP-0077662-B1 | PREPARATION OF NITROARYLACETIC ACID ESTERS AND DERIVATIVES THEREOF | ETHYL CORPORATION (US) | 1985-10-02 | — | — | EP | disclosed |
| US-4511729-A | Nucleophilic substitution process | ETHYL CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| US-4502996-A | Nucleophilic substitution process | ETHYL CORPORATION (US) | 1985-03-05 | — | — | US | disclosed |
| US-4502998-A | Nucleophilic substitution process | ETHYL CORPORATION (US) | 1985-03-05 | — | — | US | disclosed |
| US-4499026-A | Nucleophilic substitution process | ETHYL CORPORATION (US) | 1985-02-12 | — | — | US | disclosed |
| US-4476315-A | NITROARYLACETIC ACID ESTERS FROM NITROAROMATIC COMPOUNDS | ETHYL CORPORATION (US) | 1984-10-09 | — | — | US | disclosed |
| EP-0078709-A2 | Preparation of nitroaralkyl cyanides and derivatives thereof | ETHYL CORPORATION (US) | 1983-05-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019046-A1 | Phenylacetamido-pyrazole derivatives and their use as antitumor agents | DCK, CCNK, CDK2 | KMT2A 1495/4885MEN1 3802/4885TP53 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.