Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.44 |
| ▸ | HTR7 | P34969 | 5/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | MTTP | P55157 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6789349 | 0.89 | HTR7 (0.45) | HTR1AHTR7DRD2HTR2AHTR2C | |
| SCHEMBL6792842 | 0.87 | DRD3 (0.46) | HTR7DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL6791987 | 0.86 | GAA (0.47) | HTR1ADRD2DRD3 | |
| SCHEMBL6790988 | 0.86 | DRD3 (0.46) | HTR7DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL6797449 | 0.85 | HTR2A (0.52) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL6800314 | 0.83 | HTR1A (0.46) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL6793341 | 0.83 | HTR1A (0.46) | HTR1AHTR7DRD2HTR2ADRD4 | |
| SCHEMBL6792470 | 0.83 | HTR7 (0.45) | HTR1AHTR7DRD2DRD4DRD3 | |
| SCHEMBL6792149 | 0.83 | MTTP (0.59) | DRD3CHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL6790535 | 0.83 | HTR1A (0.50) | HTR1AHTR7DRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818644-B1 | FLUORENE-9-CARBOXYLIC AMIDES; INHIBITORS OF MICROSOMAL TRIGLYSERIDE-TRANSFER PROTEIN (MTP); ANTILIPEMIC AGENTS; ATHEROSCLEROSIS, DIABETES, EATING DISORDERS, AND PANCREATITIS | BOEHRINGER INGELHEIM PHARM GMBH & CO, KG (DE) | 2004-11-16 | — | — | US | disclosed |