Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ME2 | P23368 | 1/20 | 0.43 |
| ▸ | ME1 | P48163 | 1/20 | 0.43 |
| ▸ | ME3 | Q16798 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6792965 | 0.93 | GAA (0.52) | GAACACNA1GHTR1ALMNAREV1 | |
| SCHEMBL6795176 | 0.91 | PKM (0.52) | CACNA1GHTR1ADRD2DRD3 | |
| SCHEMBL6789349 | 0.89 | HTR7 (0.45) | HTR1ADRD2DRD3 | |
| SCHEMBL6792842 | 0.87 | DRD3 (0.46) | DRD2DRD3 | |
| SCHEMBL6794501 | 0.87 | HTR1A (0.49) | GAAHTR1ADRD2ALDH1A1LMNA | |
| SCHEMBL6797449 | 0.86 | HTR2A (0.52) | HTR1ADRD2DRD3 | |
| SCHEMBL6789329 | 0.86 | HTR1A (0.44) | HTR1ADRD2DRD3 | |
| SCHEMBL6790988 | 0.85 | DRD3 (0.46) | DRD2DRD3 | |
| SCHEMBL6792149 | 0.85 | MTTP (0.59) | DRD3 | |
| SCHEMBL6790535 | 0.85 | HTR1A (0.50) | CACNA1GHTR1ADRD2POLBDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818644-B1 | FLUORENE-9-CARBOXYLIC AMIDES; INHIBITORS OF MICROSOMAL TRIGLYSERIDE-TRANSFER PROTEIN (MTP); ANTILIPEMIC AGENTS; ATHEROSCLEROSIS, DIABETES, EATING DISORDERS, AND PANCREATITIS | BOEHRINGER INGELHEIM PHARM GMBH & CO, KG (DE) | 2004-11-16 | — | — | US | disclosed |