Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.46 |
| ▸ | HTR7 | P34969 | 6/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6791421 | 0.99 | HTR1A (0.45) | HTR1AHTR7DRD2DRD3HTR2A | |
| SCHEMBL6793341 | 0.98 | HTR1A (0.46) | HTR1AHTR7DRD2DRD3HTR2A | |
| SCHEMBL6790535 | 0.96 | HTR1A (0.50) | HTR1AHTR7DRD2DRD3HTR2A | |
| SCHEMBL6789349 | 0.84 | HTR7 (0.45) | HTR1AHTR7DRD2DRD3HTR2A | |
| SCHEMBL6792470 | 0.84 | HTR7 (0.45) | HTR1AHTR7DRD2DRD3KCNH2 | |
| SCHEMBL6789329 | 0.83 | HTR1A (0.44) | HTR1AHTR7DRD2DRD3HTR2A | |
| SCHEMBL6791987 | 0.83 | GAA (0.47) | HTR1ADRD2DRD3ALDH1A1 | |
| SCHEMBL6793118 | 0.82 | HTR7 (0.46) | HTR1AHTR7DRD2DRD3HTR2A | |
| SCHEMBL6792842 | 0.82 | DRD3 (0.46) | HTR7DRD2DRD3HTR2AKCNH2 | |
| SCHEMBL6797449 | 0.81 | HTR2A (0.52) | HTR1AHTR7DRD2DRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818644-B1 | FLUORENE-9-CARBOXYLIC AMIDES; INHIBITORS OF MICROSOMAL TRIGLYSERIDE-TRANSFER PROTEIN (MTP); ANTILIPEMIC AGENTS; ATHEROSCLEROSIS, DIABETES, EATING DISORDERS, AND PANCREATITIS | BOEHRINGER INGELHEIM PHARM GMBH & CO, KG (DE) | 2004-11-16 | — | — | US | disclosed |