Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 6/20 | 0.51 |
| ▸ | MMP7 | P09237 | 3/20 | 0.51 |
| ▸ | MMP14 | P50281 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.50 |
| ▸ | MMP9 | P14780 | 3/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.46 |
| ▸ | MMP3 | P08254 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5491920 | 0.79 | HSD11B1 (0.56) | MMP2MMP7MMP14ALDH1A1HSD11B1 | |
| SCHEMBL8572063 | 0.78 | ALDH1A1 (0.61) | ALDH1A1HSD11B1 | |
| SCHEMBL3671530 | 0.77 | NPC1 (0.69) | NPC1MMP2MMP7MMP14ALDH1A1 | |
| SCHEMBL7787828 | 0.76 | HSD11B1 (0.50) | NPC1ALDH1A1KDM4EHSD11B1MMP1 | |
| SCHEMBL6554003 | 0.75 | NPC1 (0.67) | NPC1MMP2MMP7MMP14ALDH1A1 | |
| SCHEMBL6554026 | 0.75 | NPC1 (0.67) | NPC1MMP2MMP7MMP14ALDH1A1 | |
| SCHEMBL6554020 | 0.75 | NPC1 (0.67) | NPC1MMP2MMP7MMP14ALDH1A1 | |
| SCHEMBL6554000 | 0.75 | NPC1 (0.67) | NPC1MMP2MMP7MMP14ALDH1A1 | |
| SCHEMBL7210507 | 0.74 | HTT (0.58) | ALDH1A1HSD11B1MMP1MMP13 | |
| SCHEMBL7010857 | 0.73 | HSD11B1 (0.58) | NPC1MMP2MMP7MMP14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6765003-B1 | ANTICARCINOGENIC, ANTITUMOR, AND ANTIMETASTASIS AGENTS; RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, MULTIPLE SCLEROSIS, STROKE, ARTERIOSCLEROSIS, | PHARMACIA ITALIA, SPA (IT) | 2004-07-20 | — | — | US | disclosed |
| EP-1200398-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001005756-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-01-25 | — | — | WO | disclosed |