Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11839176 | 0.92 | DRD2 (0.57) | DRD2HTR1AHTR2ANOTUMSLC18A3 | |
| SCHEMBL28752384 | 0.89 | DRD2 (0.55) | DRD2HTR1AHTR2ANOTUMSLC18A3 | |
| SCHEMBL11823970 | 0.88 | DRD2 (0.52) | DRD2HTR1AHTR2ANOTUMSLC18A3 | |
| SCHEMBL6792592 | 0.86 | DRD2 (0.52) | DRD2HTR1AHTR2ANOTUMSLC18A3 | |
| SCHEMBL6796674 | 0.84 | DRD2 (0.63) | DRD2HTR1AHTR2ANOTUMDRD4 | |
| SCHEMBL3958993 | 0.82 | DRD2 (0.51) | DRD2HTR1AHTR2ANOTUMSLC18A3 | |
| SCHEMBL9014839 | 0.81 | DRD2 (0.54) | DRD2HTR1AHTR2ASLC18A3SIGMAR1 | |
| SCHEMBL7216011 | 0.78 | DRD2 (0.50) | DRD2HTR1AHTR2ANOTUMADRA1B | |
| SCHEMBL11833053 | 0.77 | SLC18A3 (0.45) | DRD2HTR1AHTR2ASLC18A3SIGMAR1 | |
| SCHEMBL9014725 | 0.77 | KCNH2 (0.63) | DRD2HTR1AHTR2ASLC18A3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040044007-A1 | Indoline derivatives | H. LUNDBECK A/S (DK) | 2004-03-04 | — | — | US | claimed |
| US-20040044007-A1 | Indoline derivatives | H. LUNDBECK A/S (DK) | 2004-03-04 | — | — | US | disclosed |
| EP-1345921-A1 | 3-INDOLINE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC AND NEUROLOGIC DISORDERS | H. Lundbeck A/S (DK) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002051833-A1 | 3-INDOLINE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC AND NEUROLOGIC DISORDERS | H. LUNDBECK A/S (DK) | 2002-07-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044007-A1 | Indoline derivatives | CNR1, GRIN2C, HTR3C | DRD2 43/4885HTR1A 7/4885HTR2A 117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.