Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | QDPR | P09417 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 2/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014708 | 0.91 | KCNH2 (0.61) | KCNH2PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9014839 | 0.87 | DRD2 (0.54) | KCNH2DRD2HTR1AHTR2ASLC18A3 | |
| SCHEMBL9014370 | 0.86 | KCNH2 (0.70) | KCNH2PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9014780 | 0.83 | KCNH2 (0.66) | KCNH2QDPRDRD2HTR2C | |
| SCHEMBL9014652 | 0.83 | KCNH2 (0.48) | KCNH2DRD2HTR1AHTR2ACCR5 | |
| SCHEMBL9014362 | 0.82 | KCNH2 (0.65) | KCNH2QDPRDRD2HTR2C | |
| SCHEMBL9014375 | 0.80 | KCNH2 (0.70) | KCNH2PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9014688 | 0.78 | KCNH2 (0.67) | KCNH2DRD2DRD4 | |
| SCHEMBL6792592 | 0.78 | DRD2 (0.52) | KCNH2DRD2HTR1AHTR2ASLC18A3 | |
| SCHEMBL9014672 | 0.78 | DRD2 (0.55) | KCNH2DRD2SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |