Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 4/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10518666 | 1.00 | TDP1 (0.41) | TDP1CYP3A4TP53ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL18241085 | 0.95 | TDP1 (0.41) | TDP1CYP3A4TP53ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL30528109 | 0.95 | TDP1 (0.41) | TDP1CYP3A4TP53ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL28618359 | 0.95 | TDP1 (0.41) | TDP1CYP3A4TP53ESR1ESR2 | |
| SCHEMBL34614 | 0.95 | CYP3A4 (0.45) | TDP1CYP3A4TP53ESR1ESR2 | |
| SCHEMBL8384147 | 0.92 | CYP3A4 (0.43) | TDP1CYP3A4TP53ESR1ESR2 | |
| Ammonia Solution, Strong SCHEMBL15124087 | 0.92 | CYP3A4 (0.43) | TDP1CYP3A4TP53ESR1ESR2 | |
| Hydrogen Sulfide SCHEMBL8154468 | 0.92 | TDP1 (0.43) | TDP1CYP3A4TP53ESR1ESR2 | |
| SCHEMBL3749691 | 0.92 | CYP3A4 (0.43) | TDP1CYP3A4TP53ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL11570690 | 0.92 | CYP3A4 (0.43) | TDP1CYP3A4TP53ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130102780-A1 | TRANSITION METAL-CATALYZED PROCESSES FOR THE PREPARATION OF N-ALLYL COMPOUNDS AND USE THEREOF | RHODES TECHNOLOGIES (US) | 2013-04-25 | — | — | US | claimed |
| EP-2580201-A2 | TRANSITION METAL-CATALYZED PROCESSES FOR THE PREPARATION OF N-ALLYL COMPOUNDS AND USE THEREOF | Rhodes Technologies (US) | 2013-04-17 | — | — | EP | claimed |
| WO-2011154827-A2 | TRANSITION METAL-CATALYZED PROCESSES FOR THE PREPARATION OF N-ALLYL COMPOUNDS AND USE THEREOF | RHODES TECHNOLOGIES (US) | 2011-12-15 | — | — | WO | claimed |
| CN-101809059-A | Method for the production of thiophene oligomers | BAYER TECHNOLOGY SERVICES GMBH | 2010-08-18 | — | — | CN | claimed |
| CN-101778883-A | Method for producing polythiophenes and oligothiophenes on an industrial scale | BAYER TECHNOLOGY SERVICES GMBH | 2010-07-14 | — | — | CN | claimed |
| JP-1168787-A | — | — | None | — | — | JP | disclosed |
| US-9657030-B2 | Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof | RHODES TECHNOLOGIES (US) | 2017-05-23 | — | — | US | disclosed |
| US-9624232-B2 | Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof | RHODES TECHNOLOGIES (US) | 2017-04-18 | — | — | US | disclosed |
| US-9593124-B2 | Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof | RHODES TECHNOLOGIES (US) | 2017-03-14 | — | — | US | disclosed |
| US-9499557-B2 | Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof | RHODES TECHNOLOGIES (US) | 2016-11-22 | — | — | US | disclosed |
| EP-2995614-A1 | TRANSITION METAL-CATALYZED PROCESSES FOR THE PREPARATION OF N-ALLYL COMPOUNDS AND USE THEREOF | Rhodes Technologies Inc. (US) | 2016-03-16 | — | — | EP | disclosed |
| US-20150353569-A1 | TRANSITION METAL-CATALYZED PROCESSES FOR THE PREPARATION OF N-ALLYL COMPOUNDS AND USE THEREOF | NORAMCO, LLC | 2015-12-10 | — | — | US | disclosed |
| US-20120010452-A1 | HETEROGENEOUS SUPPORTS FOR HOMOGENEOUS CATALYSTS | CONOCOPHILLIPS COMPANY - IP SERVICES GROUP (US) | 2012-01-12 | — | — | US | disclosed |
| WO-2012005840-A1 | HETEROGENEOUS SUPPORTS FOR HOMOGENEOUS CATALYSTS | CONOCOPHILLIPS COMPANY - IP SERVICES GROUP (US) | 2012-01-12 | — | — | WO | disclosed |
| WO-2011154827-A2 | TRANSITION METAL-CATALYZED PROCESSES FOR THE PREPARATION OF N-ALLYL COMPOUNDS AND USE THEREOF | RHODES TECHNOLOGIES (US) | 2011-12-15 | — | — | WO | disclosed |
| CN-101809059-A | Method for the production of thiophene oligomers | BAYER TECHNOLOGY SERVICES GMBH | 2010-08-18 | — | — | CN | disclosed |
| CN-101778883-A | Method for producing polythiophenes and oligothiophenes on an industrial scale | BAYER TECHNOLOGY SERVICES GMBH | 2010-07-14 | — | — | CN | disclosed |
| WO-2000021577-A2 | COMPOSITIONS | NYCOMED IMAGING AS (NO) | 2000-04-20 | — | — | WO | disclosed |
| US-5028629-A | 2-(Substituted)-N-Hydroxy-N-Alkylcinnamamides | ELI LILLY AND COMPANY (US) | 1991-07-02 | — | — | US | disclosed |
| JP-H01168787-A | PLASTIC SCINTILLATOR AND ITS PREPARATION | HAMAMATSU PHOTONICS KK | 1989-07-04 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353569-A1 | TRANSITION METAL-CATALYZED PROCESSES FOR THE PREPARATION OF N-ALLYL COMPOUNDS AND USE THEREOF | OPRK1, OPRM1, OPRD1 | ACHE 8/4885TDP1 642/4885CYP3A4 19/4885 |
| US-20130102780-A1 | TRANSITION METAL-CATALYZED PROCESSES FOR THE PREPARATION OF N-ALLYL COMPOUNDS AND USE THEREOF | OPRK1, OPRM1, OPRD1 | ACHE 8/4885TDP1 642/4885CYP3A4 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.