SCHEMBL6791955

SCHEMBL6791955

Cn1ncc2[nH]c3ccc(F)c(F)c3c(=O)c21

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.38
HTR2A P28223 2/20 0.37
HTR6 P50406 2/20 0.37
HRH4 Q9H3N8 2/20 0.32
HTR7 P34969 1/20 0.32
EGLN1 Q9GZT9 1/20 0.32
F2RL1 P55085 1/20 0.31
GPR84 Q9NQS5 1/20 0.30
P2RX7 Q99572 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6785754 0.87 EGLN1 (0.34) DAOHRH4EGLN1F2RL1
SCHEMBL6788043 0.83 FEN1 (0.42) DAOHTR6HTR7EGLN1
SCHEMBL6788140 0.78 PDE3B (0.33) EGLN1
SCHEMBL6785738 0.76 POLB (0.39) DAO
SCHEMBL6786900 0.74 KDM4E (0.51)
SCHEMBL6787756 0.74
SCHEMBL6787118 0.74 MPO (0.38) DAO
SCHEMBL6781822 0.72 DAO (0.34) DAO
SCHEMBL6787376 0.72 DAO (0.38) DAOHRH4EGLN1F2RL1
SCHEMBL6783202 0.71 FEN1 (0.42) DAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6686373-B2 ANALGESICS; ANTIINFLAMMATORY AGENT WARNER-LAMBERT COMPANY LLC 2004-02-03 US disclosed
US-20030130277-A1 Pyrazoloquinolinone derivatives as protein kinase C inhibitors KAWAMURA KIYOSHI (JP) 2003-07-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030130277-A1 Pyrazoloquinolinone derivatives as protein kinase C inhibitors PRKCB, PRKCA, PRKCG DAO 1867/4885HTR2A 1518/4885HTR6 2429/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.