Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 12/20 | 0.39 |
| ▸ | CDK1 | P06493 | 8/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | RHEB | Q15382 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6786300 | 0.99 | KDM4C (0.43) | KDM4CCDK2CDK1CCNA2CCNB1 | |
| SCHEMBL6791015 | 0.79 | DGAT2 (0.42) | — | |
| SCHEMBL4360432 | 0.71 | CDK2 (0.60) | CDK2CDK1CCNA2CCNB1CCNA1 | |
| SCHEMBL28275390 | 0.69 | CDK2 (0.42) | KDM4CCDK2CDK1CCNA2CCNB1 | |
| SCHEMBL9251890 | 0.65 | PDE5A (0.48) | KDM4CPDE5APDE4APDE4BPDE4C | |
| SCHEMBL31439122 | 0.65 | CDK2 (0.72) | CDK2CDK1CCNA2CCNB1CCNA1 | |
| SCHEMBL6792082 | 0.61 | MAOA (0.33) | KDM4CCDK2 | |
| SCHEMBL15129025 | 0.60 | MAPK8 (0.46) | KDM4CCDK2CDK1 | |
| SCHEMBL5417131 | 0.60 | ROCK2 (0.49) | CDK2 | |
| SCHEMBL13530549 | 0.60 | DCK (0.46) | CDK2CDK1CCNA2CCNB1CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040110775-A1 | Cyclin dependent kinase inhibiting purine derivatives | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2004-06-10 | — | — | US | disclosed |
| EP-1353922-A1 | CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES | Cancer Research Technology Limited (GB) | 2003-10-22 | — | — | EP | disclosed |
| WO-2002059125-A1 | CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110775-A1 | Cyclin dependent kinase inhibiting purine derivatives | CCNA1, CDKL1, CCNK | KDM4C 792/4885CDK2 13/4885CDK1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.