Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4257701 | 0.95 | ROCK2 (0.39) | ROCK2KDM4CNAMPTADAM17KDM4E | |
| Trifluoroacetic Acid SCHEMBL1658074 | 0.88 | ROCK2 (0.37) | ROCK2KDM4CNAMPTKDM4EALDH1A1 | |
| SCHEMBL4257707 | 0.87 | ROCK2 (0.38) | ROCK2NAMPTKDM4ENPC1ALDH1A1 | |
| SCHEMBL6791734 | 0.86 | ROCK2 (0.41) | ROCK2KDM4CNAMPTADAM17MAPT | |
| Trifluoroacetic Acid SCHEMBL6793066 | 0.86 | ROCK2 (0.38) | ROCK2KDM4ENPC1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL1656611 | 0.84 | ROCK2 (0.35) | ROCK2KDM4CNAMPT | |
| SCHEMBL1656621 | 0.83 | CCNA2 (0.36) | ADAM17KDM4ENPC1ALDH1A1MAPT | |
| Trifluoroacetic Acid SCHEMBL4270585 | 0.83 | CDK2 (0.33) | ROCK2NAMPTKDRPDPK1CDK2 | |
| SCHEMBL5484987 | 0.83 | ROCK2 (0.34) | ROCK2NAMPTPDPK1CDK2 | |
| Trifluoroacetic Acid SCHEMBL6787470 | 0.83 | ALDH1A1 (0.36) | ROCK2NAMPTKDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | ROCK2 317/4885KDM4C 3390/4885NAMPT 658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.