Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.32 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4257701 | 0.91 | ROCK2 (0.39) | ROCK2ALDH1A1NPC1KDM4ECDK2 | |
| Trifluoroacetic Acid SCHEMBL6788639 | 0.90 | ALDH1A1 (0.39) | ROCK2P2RY12ALDH1A1NPC1CDK4 | |
| SCHEMBL4257707 | 0.89 | ROCK2 (0.38) | ROCK2ALDH1A1NPC1KDM4E | |
| SCHEMBL6792350 | 0.86 | ROCK2 (0.42) | ROCK2ALDH1A1NPC1KDM4ECDK2 | |
| Trifluoroacetic Acid SCHEMBL1658074 | 0.84 | ROCK2 (0.37) | ROCK2ALDH1A1KDM4ECDK2HPGD | |
| Trifluoroacetic Acid SCHEMBL6801179 | 0.82 | CDK4 (0.32) | ROCK2CDK4CCNA2CDK2CCND3 | |
| SCHEMBL1658076 | 0.82 | ROCK2 (0.36) | ROCK2KDM4ESMN1; SMN2CYP2C19MEN1 | |
| Trifluoroacetic Acid SCHEMBL4271415 | 0.80 | AURKA (0.32) | ROCK2CCNA2CDK2CCNA1 | |
| Trifluoroacetic Acid SCHEMBL4270585 | 0.80 | CDK2 (0.33) | ROCK2CCNA2CDK2CCNA1 | |
| Trifluoroacetic Acid SCHEMBL6792793 | 0.79 | CDK2 (0.37) | ROCK2ALDH1A1NPC1KDM4ECDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | ROCK2 317/4885P2RY12 715/4885ALDH1A1 4449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.