Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | USP5 | P45974 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MMP13 | P45452 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27576284 | 0.87 | MAPT (0.47) | SMN1; SMN2HTTRECQLALDH1A1MAPT | |
| SCHEMBL6098631 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2HTTRECQLALDH1A1MAPT | |
| SCHEMBL6095340 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2HTTRECQLALDH1A1MAPT | |
| SCHEMBL6094119 | 0.80 | MMP13 (0.57) | EPHX2MMP13MMP12MMP14 | |
| SCHEMBL6096540 | 0.80 | MMP13 (0.57) | USP5EPHX2MMP13MMP12MMP14 | |
| SCHEMBL6136613 | 0.78 | CYP1A2 (0.50) | HTTALDH1A1MAPTEPHX2POLB | |
| SCHEMBL6097192 | 0.75 | SMN1; SMN2 (0.40) | SMN1; SMN2HTTRECQLALDH1A1MAPT | |
| SCHEMBL9014017 | 0.75 | ALDH1A1 (0.55) | ALDH1A1MAPTEPHX2LMNAPOLB | |
| SCHEMBL11044966 | 0.74 | EPHX2 (0.54) | SMN1; SMN2ALDH1A1MAPTEPHX2LMNA | |
| SCHEMBL16532717 | 0.74 | SIGMAR1 (0.45) | SMN1; SMN2HTTRECQLALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6800646-B1 | Sulfamato hydroxamic acid metalloprotease inhibitor | PHARMACIA CORPORATION | 2004-10-05 | — | — | US | disclosed |
| US-6492367-B1 | Sulfamato hydroxamic acid metalloprotease inhibitor | G. D. SEARLE & COMPANY | 2002-12-10 | — | — | US | disclosed |
| US-6448250-B1 | INHIBITS THE ACTIVITY OF ONE OR MORE OF THE FOLLOWING MATRIX METALLOPROTEINASES: MMP-2, MMP-9, AND MMP-13, WHILE EXHIBITING SUBSTANTIALLY LESS INHIBITORY ACTIVITY AGAINST MMP-1 | G. D. SEARLE & COMPANY | 2002-09-10 | — | — | US | disclosed |