Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.36 |
| ▸ | TUBB | P07437 | 3/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Chloride SCHEMBL28111275 | 0.94 | LMNA (0.36) | LMNASMN1; SMN2HSD17B3KDM4EPOLB | |
| SCHEMBL6783071 | 0.80 | KDM4E (0.51) | LMNASMN1; SMN2KDM4EPOLBKMT2A | |
| SCHEMBL1589975 | 0.76 | ALDH1A1 (0.44) | SMN1; SMN2KDM4EMAPTTDP1ALDH1A1 | |
| SCHEMBL6787091 | 0.75 | ATM (0.41) | LMNASMN1; SMN2HSD17B3KDM4EPOLB | |
| SCHEMBL7814302 | 0.74 | TPMT (0.41) | LMNAKDM4EPOLBMAPTKMT2A | |
| SCHEMBL6794084 | 0.74 | ALDH1A1 (0.55) | LMNAKDM4EMAPTKMT2ATDP1 | |
| Ethoxycarbonyl Group SCHEMBL28016264 | 0.73 | MAPT (0.33) | LMNASMN1; SMN2KDM4EPOLBMAPT | |
| SCHEMBL6785629 | 0.72 | SMN1; SMN2 (0.35) | LMNASMN1; SMN2KDM4EPOLBMAPT | |
| SCHEMBL14823524 | 0.71 | KDM4E (0.43) | LMNAKDM4EPOLBMAPTKMT2A | |
| SCHEMBL9621166 | 0.69 | ATM (0.41) | LMNASMN1; SMN2KDM4EPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104649879-B | Substituted benzene methylene 1,2,3,4-Tetrahydrooxonaphthalene analog derivative and preparation method, application | 中国人民解放军第二军医大学 | 2017-01-04 | — | — | CN | claimed |
| CN-104649879-A | Substituted benzylidene tetralone derivatives and preparation method and applications | UNIV PLA 2ND MILITARY MEDICAL | 2015-05-27 | — | — | CN | claimed |
| CN-106632050-B | Benzo indazole analog derivative and preparation method thereof, application | 中国人民解放军第二军医大学 | 2019-08-13 | — | — | CN | disclosed |
| CN-107011266-A | Prodrug of benzo indazole analog derivative and preparation method thereof, application | 中国人民解放军第二军医大学 | 2017-08-04 | — | — | CN | disclosed |
| CN-104649879-B | Substituted benzene methylene 1,2,3,4-Tetrahydrooxonaphthalene analog derivative and preparation method, application | 中国人民解放军第二军医大学 | 2017-01-04 | — | — | CN | disclosed |
| CN-104649879-A | Substituted benzylidene tetralone derivatives and preparation method and applications | UNIV PLA 2ND MILITARY MEDICAL | 2015-05-27 | — | — | CN | disclosed |
| US-6828316-B2 | Antiallergens | KOWA CO., LTD. (JP) | 2004-12-07 | — | — | US | disclosed |
| US-20020042414-A1 | Diamide compound and medicine containing the same | KOWA CO., LTD. (JP) | 2002-04-11 | — | — | US | disclosed |
| US-6340682-B1 | FOR THERAPY OF ALLERGIC IMMUNOLOGICAL DISEASE IS SELECTED FROM ASTHMA, ALLERGIC RHINITIS, INFLAMMATORY LARGE BOWEL DISEASE OR CONTACT DERMATITIS | KOWA CO., LTD. (JP) | 2002-01-22 | — | — | US | disclosed |
| EP-0926138-A1 | DIAMIDE COMPOUNDS AND DRUGS CONTAINING THE SAME | KOWA CO. LTD. (JP) | 1999-06-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020042414-A1 | Diamide compound and medicine containing the same | HRH4, HRH2, HRH1 | LMNA 4686/4885SMN1; SMN2 4780/4885HSD17B3 1248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.