Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | MELK | Q14680 | 1/20 | 0.40 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6782374 | 0.79 | KDM4E (0.48) | JAK2RPS6KA3MELKSTK24ALDH1A1 | |
| Isothiocyanate SCHEMBL38660131 | 0.76 | KDM4E (0.42) | JAK2RPS6KA3MELKSTK24ALDH1A1 | |
| SCHEMBL30085683 | 0.76 | CD44 (0.41) | ALDH1A1HSD17B10CYP3A4HPGDTSHR | |
| SCHEMBL29549299 | 0.75 | HSD17B10 (0.64) | JAK2RPS6KA3MELKSTK24ALDH1A1 | |
| SCHEMBL689822 | 0.75 | HSD17B10 (0.64) | JAK2RPS6KA3MELKSTK24ALDH1A1 | |
| SCHEMBL31253333 | 0.75 | MAPT (0.46) | ALDH1A1HSD17B10CYP3A4HPGDTSHR | |
| SCHEMBL165079 | 0.75 | MAPT (0.46) | ALDH1A1HSD17B10CYP3A4HPGDTSHR | |
| SCHEMBL29349435 | 0.74 | JAK2 (0.54) | JAK2RPS6KA3MELKSTK24ALDH1A1 | |
| SCHEMBL65699 | 0.74 | JAK2 (0.54) | JAK2RPS6KA3MELKSTK24ALDH1A1 | |
| SCHEMBL25248681 | 0.73 | JAK2 (0.39) | JAK2RPS6KA3MELKSTK24F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002032856-A9 | INSECTICIDAL 1,8-NAPHTHALENEDICARBOXAMIDES | DU PONT (US) | 2004-04-08 | — | — | WO | disclosed |
| US-20040053786-A1 | Insecticidal 1,8-naphthalenedicarboxamides | E.I. DU PONT DE NEMOURS AND COMPANY | 2004-03-18 | — | — | US | disclosed |
| EP-1326827-A2 | INSECTICIDAL 1,8-NAPHTHALENEDICARBOXAMIDES | E. I. du Pont de Nemours and Company (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032856-A2 | INSECTICIDAL 1,8-NAPHTHALENEDICARBOXAMIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2002-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053786-A1 | Insecticidal 1,8-naphthalenedicarboxamides | DDT, NIT2, ACHE | JAK2 4633/4885RPS6KA3 2700/4885MELK 4498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.