Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.40 |
| ▸ | TPH1 | P17752 | 1/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | ABAT | P80404 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6794018 | 1.00 | HDAC3 (0.48) | HDAC3HDAC6NCOR2LOXL2F10 | |
| SCHEMBL15599673 | 0.77 | MAPT (0.54) | SMN1; SMN2CYP1A2TSHRCYP2C19 | |
| SCHEMBL17504830 | 0.77 | MAPT (0.54) | SMN1; SMN2CYP1A2TSHRCYP2C19 | |
| SCHEMBL5177381 | 0.76 | LMNA (0.45) | LOXL2SMN1; SMN2PLA2G10PLA2G2APLAU | |
| SCHEMBL5045569 | 0.76 | LMNA (0.45) | LOXL2SMN1; SMN2PLA2G10PLA2G2APLAU | |
| SCHEMBL5154701 | 0.75 | LOXL2 (0.56) | HDAC3HDAC6NCOR2LOXL2F10 | |
| SCHEMBL4253164 | 0.75 | LOXL2 (0.56) | HDAC3HDAC6NCOR2LOXL2F10 | |
| SCHEMBL4253161 | 0.75 | LOXL2 (0.56) | HDAC3HDAC6NCOR2LOXL2F10 | |
| Hydrochloric Acid SCHEMBL5045565 | 0.75 | MAOB (0.45) | HDAC3SMN1; SMN2PLA2G10PLA2G2APLAU | |
| Hydrochloric Acid SCHEMBL5045567 | 0.75 | MAOB (0.45) | HDAC3SMN1; SMN2PLA2G10PLA2G2APLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082585-A1 | Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade | PHARMACIA CORPORATION | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082585-A1 | Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade | TFPI, F2, PLG | HDAC3 466/4885HDAC6 2119/4885NCOR2 3243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.