Scoulerine

Scoulerine

SCHEMBL679505

COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(O)c3CN1CC2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DRD1 P21728 18/20 1.00
DRD2 P14416 11/20 1.00
KDM4E B2RXH2 1/20 1.00
LMNA P02545 1/20 1.00
CYP1A2 P05177 1/20 1.00
CYP3A4 P08684 1/20 1.00
CYP2D6 P10635 1/20 1.00
CASP1 P29466 1/20 1.00
CYP2C19 P33261 1/20 1.00
APAF1 O14727 1/20 1.00
BCHE P06276 1/20 1.00
L3MBTL1 Q9Y468 1/20 1.00
F3 P13726 6/20 0.87
DRD3 P35462 6/20 0.81
DRD5 P21918 3/20 0.81
SIGMAR1 Q99720 3/20 0.81
DRD4 P21917 2/20 0.81
HTR1A P08908 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Discretamine SCHEMBL13885928 1.00 DRD1 (1.00) DRD1DRD2KDM4ELMNACYP1A2
Scoulerine SCHEMBL29617585 1.00 DRD1 (1.00) DRD1DRD2KDM4ELMNACYP1A2
Discretamine SCHEMBL29362664 1.00 DRD1 (1.00) DRD1DRD2KDM4ELMNACYP1A2
Scoulerine SCHEMBL29462969 1.00 DRD1 (1.00) DRD1DRD2KDM4ELMNACYP1A2
Discretamine SCHEMBL4202179 0.99 DRD1 (0.98) DRD1DRD2KDM4ELMNACYP1A2
Tetrahydropalmatrubine SCHEMBL20759895 0.93 DRD1 (1.00) DRD1DRD2KDM4ELMNACYP1A2
Tetrahydropalmatrubine SCHEMBL12904352 0.93 DRD1 (1.00) DRD1DRD2KDM4ELMNACYP1A2
SCHEMBL680031 0.90 DRD1 (1.00) DRD1DRD2KDM4ELMNACYP1A2
SCHEMBL29561422 0.90 DRD1 (1.00) DRD1DRD2KDM4ELMNACYP1A2
SCHEMBL14703846 0.90 DRD1 (1.00) DRD1DRD2KDM4ELMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 395 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4687856-A2 GLP-1R AGONIST AND DPP-4 INHIBITOR COMPOSITIONS AND METHODS OF USING JDS Therapeutics, LLC (US) 2026-02-11 EP claimed
WO-2025031833-A1 RECOMBINANT STRAIN AND USE THEREOF IN PRODUCTION OF SCOULERINE CHRYSEA LIMITED (IE) 2025-02-13 WO claimed
US-20240415129-A1 BOTANICAL BASED BIO-INSECTICIDAL COMPOSITIONS FOR CONTROLLING PESTS AND IMPROVING THE PLANT PHYSIOLOGICAL PROCESS KAY BEE BIO ORGANICS PVT LTD (IN) 2024-12-19 US claimed
US-20240366525-A1 GLP-1R AGONIST AND DPP-4 INHIBITOR COMPOSITIONS AND METHODS OF USING JDS THERAPEUTICS, LLC 2024-11-07 US claimed
WO-2024229159-A2 GLP-1R AGONIST AND DPP-4 INHIBITOR COMPOSITIONS AND METHODS OF USING JDS THERAPEUTICS, LLC (US) 2024-11-07 WO claimed
US-12091696-B2 O-methyltransferase protein with highly specific catalytic function for multiple bias parent nuclei and encoding gene and use thereof INSTITUTE OF CHINESE MATERIA MEDICA CHINA ACADEMY OF CHINESE MEDICAL SCIENCES (CN) 2024-09-17 US claimed
US-20240240194-A1 TRANSCRIPTION FACTOR SUN PHARMACEUTICAL INDUSTRIES AUSTRALIA PTY LIMITED (AU) 2024-07-18 US claimed
EP-4347846-A1 TRANSCRIPTION FACTOR Sun Pharmaceutical Industries Australia PTY Limited (AU) 2024-04-10 EP claimed
US-20240052388-A1 O-METHYLTRANSFERASE PROTEIN WITH HIGHLY SPECIFIC CATALYTIC FUNCTION FOR MULTIPLE BIAS PARENT NUCLEI AND ENCODING GENE AND USE THEREOF INSTITUTE OF CHINESE MATERIA MEDICA CHINA ACADEMY OF CHINESE MEDICAL SCIENCES (CN) 2024-02-15 US claimed
WO-2024015152-A1 TETRAHYDROPAPAVERINE-PRODUCING MICROBES AND METHODS OF MAKING AND USING THE SAME THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2024-01-18 WO claimed
US-20110224141-A1 METHODS AND RELATED COMPOSITIONS FOR THE TREATMENT OF CANCER STC.UNM (US) 2011-09-15 US claimed
WO-2011087765-A2 METHODS OF PRODUCING STABILIZED SOLID PHARMACEUTICAL COMPOSITIONS CONTAINING MORPHINANS MALLINCKRODT INC. (US) 2011-07-21 WO claimed
US-20110150989-A1 Methods of Producing Stabilized Solid Dosage Pharmaceutical Compositions Containing Morphinans Mallinkckrodt Inc. (US) 2011-06-23 US claimed
CN-102078319-A Application of dehydrocorydaline and scoulerine to medicament production UNIV SUN YAT SEN 2011-06-01 CN claimed
WO-2011041470-A2 SUSTAINED-RELEASE OPIATE AND OPIATE DERIVATIVE COMPOSITIONS MALLINCKRODT INC. (US) 2011-04-07 WO claimed
US-20110077222-A1 Sustained-Release Opiate and Opiate Derivative Compositions MALLINCKRODT INC. (US) 2011-03-31 US claimed
WO-2009148623-A2 METHODS AND RELATED COMPOSITIONS FOR THE TREATMENT OF CANCER STC.UNM (US) 2009-12-10 WO claimed
US-20090036387-A1 NOVEL CHEMICAL ENTITIES AFFECTING NEUROBLASTOMA TUMOR-INITIATING CELLS THE HOSPITAL FOR SICK CHILDREN (CA) 2009-02-05 US claimed
US-20080176754-A1 COMPOSITIONS AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS HERCULES CAPITAL, INC., AS AGENT 2008-07-24 US claimed
WO-2008067070-A2 COMPOSITIONS AND METHODS FOR PRODUCING BENZYLISOQUINOLINES ALKALOIDS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2008-06-05 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110150989-A1 Methods of Producing Stabilized Solid Dosage Pharmaceutical Compositions Containing Morphinans LPXN, FSCN1, NCLN DRD1 963/4885DRD2 1084/4885KDM4E 4729/4885
US-20110077222-A1 Sustained-Release Opiate and Opiate Derivative Compositions OPRL1, OPRK1, OPRM1 DRD1 213/4885DRD2 85/4885KDM4E 3460/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.