SCHEMBL6795327

SCHEMBL6795327

C[C@H](NC(=O)c1ccccn1)c1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 5/20 0.52
SMO Q99835 1/20 0.49
KLRK1 P26718 1/20 0.49
MICA Q29983 1/20 0.49
RAET1L Q5VY80 1/20 0.49
PDE2A O00408 4/20 0.49
MTTP P55157 3/20 0.47
APOB P04114 1/20 0.47
GRM4 Q14833 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6794114 1.00 TRPV1 (0.52) TRPV1SMOKLRK1MICARAET1L
SCHEMBL31739129 0.85 PDE2A (0.61) PDE2A
SCHEMBL6793271 0.82 TRPV1 (0.64) TRPV1SMOMTTPAPOBGRM4
SCHEMBL6794893 0.81 POLB (0.53) TRPV1SMOMTTPAPOB
SCHEMBL6796384 0.81 SMO (0.55) TRPV1SMOMTTPAPOBGRM4
SCHEMBL6792071 0.81 TRPV1 (0.78) TRPV1SMOMTTPAPOB
SCHEMBL6788931 0.80 TRPV1 (0.54) TRPV1SMOMTTPAPOB
SCHEMBL6792858 0.79 TRPV1 (0.52) TRPV1SMOKLRK1MICARAET1L
SCHEMBL6792851 0.79 TRPV1 (0.52) TRPV1SMOKLRK1MICARAET1L
SCHEMBL6793033 0.79 TRPV1 (0.52) TRPV1SMOMTTPAPOBGRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-03-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors APOB, APOL1, SCARB1 TRPV1 3714/4885SMO 2094/4885KLRK1 1285/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.