SCHEMBL6795504

SCHEMBL6795504

CC(C)(C)OC(=O)Nc1nc(CCN(C(=O)OC(C)(C)C)c2ccc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)cc2)cs1

nearest known ligand 0.45

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MTTP P55157 13/20 0.42
APOB P04114 7/20 0.42
TP53 P04637 2/20 0.39
SMO Q99835 1/20 0.39
MAPT P10636 1/20 0.39
RXFP1 Q9HBX9 1/20 0.38
SIRT1 Q96EB6 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6795163 0.92 KMT2A (0.38) MAPTSIRT1
SCHEMBL6491198 0.91 APOB (0.39) MTTPAPOBTP53MAPTRXFP1
SCHEMBL6794094 0.91 CCR2 (0.39) TP53SMOMAPTSIRT1
SCHEMBL6502663 0.91 APOB (0.44) MTTPAPOBTP53MAPTRXFP1
SCHEMBL6788744 0.91 NPC1 (0.41) MTTPTP53MAPTSIRT1
SCHEMBL6489412 0.89 SMO (0.45) MTTPAPOBSMO
SCHEMBL6488574 0.88 TP53 (0.45) MTTPAPOBTP53SMOMAPT
SCHEMBL6792697 0.87 MTTP (0.45) MTTPAPOBSMORXFP1
SCHEMBL6794499 0.87 CYP3A4 (0.40) MTTPTP53MAPTSIRT1
SCHEMBL6500248 0.86 APOB (0.45) MTTPAPOBTP53MAPTRXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-03-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors APOB, APOL1, SCARB1 MTTP 363/4885APOB 1/4885TP53 4865/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.