Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 17/20 | 0.65 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | ECE1 | P42892 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7893591 | 0.88 | CASP1 (0.66) | CASP1CASP3 | |
| SCHEMBL6799453 | 0.87 | CASP1 (0.56) | CASP1MMEECE1PPARA | |
| SCHEMBL6801504 | 0.86 | CASP1 (0.60) | CASP1CASP3MMEECE1 | |
| SCHEMBL6281724 | 0.85 | CASP1 (0.59) | CASP1CASP3MMEECE1 | |
| SCHEMBL6801541 | 0.85 | CASP1 (0.59) | CASP1CASP3MMEECE1 | |
| SCHEMBL554032 | 0.82 | CASP1 (0.67) | CASP1MMEECE1PPARA | |
| SCHEMBL613386 | 0.82 | CASP1 (0.67) | CASP1MMEECE1PPARA | |
| SCHEMBL376886 | 0.82 | CASP1 (0.67) | CASP1MMEECE1PPARA | |
| SCHEMBL7797640 | 0.80 | CASP1 (0.58) | CASP1CASP3MMEECE1PPARA | |
| SCHEMBL9069236 | 0.78 | CASP1 (0.59) | CASP1MMEECE1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040009923-A1 | Peptide analogs as irreversible interleukin-1beta protease inhibitors | DOLLE ROLAND E (US) | 2004-01-15 | — | — | US | disclosed |
| US-6576614-B1 | Administering methyl ketones or closed hemiketal derivatives of aspartic acid | VERTEX PHARMACEUTICALS INCORPORATED | 2003-06-10 | — | — | US | disclosed |
| US-5985838-A | TREATING INFECTIOUS DISEASE, RESPIRATORY DISEASE, INFLAMMATORY CONDITIONS, IMMUNE-BASED DISEASE, AUTO-IMMUNE DISEASE, BONE DISEASE, AND TUMORS | VERTEX PHARMACEUTICALS, INC. (US) | 1999-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009923-A1 | Peptide analogs as irreversible interleukin-1beta protease inhibitors | IL1B, IL1A, IL1RN | CASP1 6/4885CASP3 247/4885MME 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.