Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 14/20 | 0.60 |
| ▸ | ITGAV | P06756 | 14/20 | 0.60 |
| ▸ | ITGB1 | P05556 | 9/20 | 0.60 |
| ▸ | ITGB6 | P18564 | 3/20 | 0.60 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.56 |
| ▸ | MDM4 | O15151 | 1/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.54 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6804680 | 0.89 | ITGB3 (0.52) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL6803719 | 0.84 | ITGB3 (0.64) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL6805566 | 0.83 | ITGB3 (0.63) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL6809843 | 0.80 | ITGB3 (0.59) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL6803775 | 0.77 | ITGB3 (0.58) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL2836043 | 0.76 | ITGB3 (0.56) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL6800874 | 0.76 | ITGB3 (0.56) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL6771845 | 0.74 | ITGB3 (0.71) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL6698905 | 0.74 | ITGB3 (0.73) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL7013799 | 0.74 | LTA4H (0.39) | ITGB3ITGAVITGB1ITGB6MDM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040043994-A1 | Gem-substituted alpha v beta 3 antagonists | PHARMACIA CORPORATION | 2004-03-04 | — | — | US | disclosed |
| EP-1313705-A1 | GEM-SUBSTITUTED ALPHA V BETA 3 INTEGRIN ANTAGONISTS | Pharmacia Corporation (US) | 2003-05-28 | — | — | EP | disclosed |
| US-6531494-B1 | Gem-substituted αvβ3 antagonists | PHARMACIA CORPORATION | 2003-03-11 | — | — | US | disclosed |
| WO-2002018340-A1 | GEM-SUBSTITUTED α v β 3 INTEGRIN ANTAGONISTS | PHARMACIA CORPORATION (US) | 2002-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040043994-A1 | Gem-substituted alpha v beta 3 antagonists | CACNG5, ITGAV, ITGA5 | ITGB3 4/4885ITGAV 2/4885ITGB1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.