Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 8/20 | 0.52 |
| ▸ | ITGAV | P06756 | 8/20 | 0.52 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.52 |
| ▸ | ITGB6 | P18564 | 3/20 | 0.52 |
| ▸ | MDM4 | O15151 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.49 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.45 |
| ▸ | LTA4H | P09960 | 8/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6799145 | 0.89 | ITGB3 (0.60) | ITGB3ITGAVITGB1ITGB6MDM4 | |
| SCHEMBL7013799 | 0.84 | LTA4H (0.39) | ITGB3ITGAVITGB1ITGB6MDM4 | |
| SCHEMBL6800874 | 0.84 | ITGB3 (0.56) | ITGB3ITGAVITGB1ITGB6MDM4 | |
| SCHEMBL6800788 | 0.81 | ITGB3 (0.51) | ITGB3ITGAVITGB1ITGB6MDM4 | |
| SCHEMBL6803220 | 0.78 | ALDH1A1 (0.41) | — | |
| SCHEMBL6799835 | 0.77 | ESR1 (0.43) | — | |
| SCHEMBL6803775 | 0.77 | ITGB3 (0.58) | ITGB3ITGAVITGB1ITGB6MDM4 | |
| SCHEMBL6803719 | 0.76 | ITGB3 (0.64) | ITGB3ITGAVITGB1ITGB6MDM4 | |
| SCHEMBL6805566 | 0.75 | ITGB3 (0.63) | ITGB3ITGAVITGB1ITGB6MDM4 | |
| SCHEMBL6809156 | 0.74 | ITGB3 (0.44) | ITGB3ITGAVITGB1ITGB6MDM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040043994-A1 | Gem-substituted alpha v beta 3 antagonists | PHARMACIA CORPORATION | 2004-03-04 | — | — | US | disclosed |
| EP-1313705-A1 | GEM-SUBSTITUTED ALPHA V BETA 3 INTEGRIN ANTAGONISTS | Pharmacia Corporation (US) | 2003-05-28 | — | — | EP | disclosed |
| US-6531494-B1 | Gem-substituted αvβ3 antagonists | PHARMACIA CORPORATION | 2003-03-11 | — | — | US | disclosed |
| WO-2002018340-A1 | GEM-SUBSTITUTED α v β 3 INTEGRIN ANTAGONISTS | PHARMACIA CORPORATION (US) | 2002-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040043994-A1 | Gem-substituted alpha v beta 3 antagonists | CACNG5, ITGAV, ITGA5 | ITGB3 4/4885ITGAV 2/4885ITGB1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.