Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | HTR2C | P28335 | 3/20 | 0.51 |
| ▸ | HTR2B | P41595 | 3/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | METAP1 | P53582 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14409344 | 0.94 | HTR2A (0.53) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL13004977 | 0.88 | SIGMAR1 (0.62) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL18815844 | 0.88 | SMN1; SMN2 (0.59) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL6799152 | 0.85 | METAP1 (0.49) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL27081326 | 0.85 | SMN1; SMN2 (0.59) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL6801984 | 0.84 | SIGMAR1 (0.54) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL6840757 | 0.84 | SIGMAR1 (0.51) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL8778942 | 0.82 | METAP1 (0.44) | HTR2CHTR2BSIGMAR1METAP1CYP19A1 | |
| SCHEMBL2819403 | 0.81 | SMN1; SMN2 (0.51) | METAP1SMN1; SMN2MAOBACHECYP19A1 | |
| SCHEMBL11805867 | 0.81 | METAP1 (0.47) | HTR2AHTR2CHTR2BSIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071414-B | Improved process for the preparation of butorphanol tartrate | 海蔻有限公司 | 2021-11-05 | — | — | CN | disclosed |
| EP-3436425-B1 | AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE | HIKAL LTD (IN) | 2021-01-06 | — | — | EP | disclosed |
| US-10544101-B2 | Process for the preparation of butorphanol tartrate | HIKAL LIMITED (IN) | 2020-01-28 | — | — | US | disclosed |
| US-10544101-B2 | Process for the preparation of butorphanol tartrate | HIKAL LIMITED (IN) | 2020-01-28 | — | — | US | disclosed |
| US-20190112273-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE | HIKAL LIMITED (IN) | 2019-04-18 | — | — | US | disclosed |
| US-20190112273-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE | HIKAL LIMITED (IN) | 2019-04-18 | — | — | US | disclosed |
| EP-3436425-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE | Hikal Limited (IN) | 2019-02-06 | — | — | EP | disclosed |
| WO-2017168444-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE | HIKAL LIMITED (IN) | 2017-10-05 | — | — | WO | disclosed |
| EP-0606661-B1 | Octahydrophenanthrene derivatives and their use as NMDA-Antagonists | HOFFMANN LA ROCHE (CH) | 1997-03-12 | — | — | EP | disclosed |
| US-5385947-A | For prevention of nerve damage due to reduction of blood or oxygen supplies | HOFFMANN-LA ROCHE INC. (US) | 1995-01-31 | — | — | US | disclosed |
| EP-0606661-A1 | Octahydrophenanthrene derivatives and their use as NMDA-Antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1994-07-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10544101-B2 | Process for the preparation of butorphanol tartrate | OPRD1, OPRK1, OPRL1 | HTR2A 733/4885HTR2C 414/4885HTR2B 489/4885 |
| US-20190112273-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE | OPRD1, OPRL1, OPRK1 | HTR2A 563/4885HTR2C 375/4885HTR2B 426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.