Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 10/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | PRKX | P51817 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6799499 | 0.80 | PKN1 (0.64) | METAP1PARP1PLK4MAP4K4PRKX | |
| SCHEMBL6805509 | 0.79 | PARP1 (0.53) | METAP1PARP1CHEK2PARP2DHODH | |
| SCHEMBL6809996 | 0.79 | PKN1 (0.63) | PARP1PLK4MAP4K4PRKXROCK1 | |
| SCHEMBL4367704 | 0.78 | METAP1 (0.39) | METAP1PKN1PKN2CHEK2LRRK2 | |
| SCHEMBL8499134 | 0.77 | METAP1 (0.49) | METAP1PDPK1RAB9A | |
| SCHEMBL3579908 | 0.75 | PARP1 (0.61) | PARP1PLK4MAP4K4PRKXROCK1 | |
| SCHEMBL6805010 | 0.74 | METAP2 (0.53) | PARP1PLK4MAP4K4PRKXROCK1 | |
| SCHEMBL30810276 | 0.74 | PARP1 (0.45) | PARP1CHEK2AURKAPDPK1RAB9A | |
| SCHEMBL17048129 | 0.74 | KDM4E (0.56) | PARP1PLK4MAP4K4PRKXROCK1 | |
| SCHEMBL6810137 | 0.74 | NPC1 (0.47) | PARP1PLK4MAP4K4PKN1PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |